Clinical details of 182 HCV infected children
|
Blood4-150
(n = 134) |
Other4-151
(n = 8) |
MTC4-152
(n = 40) |
Total (%) (n = 182) | |
| Other associated infections | ||||
| Hepatitis B | 3 | 0 | 0 | 3 (1.7) |
| HIV infected | 5 | 0 | 6 | 11 (6.0) |
| HIV+ and hepatitis B | 1 | 0 | 0 | 1 (0.5) |
| HIV− but mother HIV+ | n/a | n/a | 4 | 4 (2.2) |
| No associated infection | 125 | 8 | 30 | 163 (89.6) |
| Reported signs and symptoms | ||||
| Liver failure4-153 | 1 | 0 | 0 | 1 (0.6) |
| Fatigue and bruising | 1 | 0 | 0 | 1 (0.6) |
| Hepatomegaly | 0 | 0 | 5 | 5 (2.8) |
| None | 132 | 8 | 35 | 175 (96.0) |
| Transaminases (AST or ALT4-154) (n = 152) | ||||
| Normal | 70 | 4 | 13 | 87 (57.2) |
| <2 × ULN | 30 | 2 | 9 | 41 (27.0) |
| 2 to <5 × ULN | 8 | 0 | 11 | 19 (12.5) |
| 5 to <10 × ULN | 3 | 1 | 1 | 5 (3.3) |
| >10 × ULN | 0 | 0 | 0 | 0 |
| Liver histology (n = 53) | ||||
| Normal | 3 | 0 | 1 | 4 (7.5) |
| Mild hepatitis | 30 | 3 | 6 | 39 (73.6) |
| Moderate hepatitis | 6 | 0 | 3 | 9 (17.0) |
| Severe hepatitis | 1 | 0 | 0 | 1 (1.9) |
| Cirrhosis | 0 | 0 | 0 | 0 |
| Genotypes (n = 73) | ||||
| 1 | 1 | 0 | 1 | 2 (2.7) |
| 1a | 18 | 0 | 6 | 24 (32.9) |
| 1b | 15 | 0 | 3 | 18 (24.7) |
| 2 | 1 | 0 | 0 | 1 (1.4) |
| 2a | 2 | 0 | 0 | 2 (2.7) |
| 2b | 2 | 0 | 0 | 2 (2.7) |
| 3 | 4 | 0 | 2 | 6 (8.2) |
| 3a | 9 | 1 | 6 | 16 (21.9) |
| 4 | 0 | 0 | 1 | 1 (1.4) |
| 5 | 1 | 0 | 0 | 1 (1.4) |