Authors, year, country |
Patients (controls) |
Patients (expt)1-150 | Experiment intervention dose | Duration | Control intervention dose | Duration |
Kleinknecht et al 18, 1982, France | 29 | 29 | Prednisone 2 mg/kg/day for 4 weeks and taper alternate days | 1 year | Prednisone 2 mg/kg/day for 4 weeks and taper alternate days | 5 months |
APN19 1-151, 1988, North Europe | 29 | 32 | Prednisone 60 mg/m2/day till urine protein free for 3 days and 40 mg/m2 alternate days till albumin >35 g/l | 1 month (average) | Prednisone 60 mg/m2/day for 4 weeks and 40 mg/m2 alternate days for 4 weeks | 2 months |
Ueda et al 20, 1988, Japan | 29 | 17 | Prednisolone 60 mg/m2/day for 4 weeks, 60 mg/m2 alternate days for 4 weeks and taper by 10 mg/m2/mth to zero | 7 months | Prednisolone 60 mg/m2/day for 4 weeks and 40 mg/m2 on 3 of 7 days for 4 weeks | 2 months |
APN21, 1993, North Europe | 37 | 34 | Prednisone—6 weeks each of 60 mg/m2/day and 40 mg/m2 alternate days | 3 months | Prednisone—4 weeks each of 60 mg/m2/day and 40 mg/m2 alternate days | 2 months |
Ksiazek and Wyszynska22, 1995, Poland | 44 | 681-152 | Prednisone 1–2 mg/kg/day for 4 weeks, 1 mg/kg alternate days for 4 weeks and taper by 25% per week for 4 weeks | 3 months | Prednisone 4 weeks each of 1–2 mg/kg/day and 1 mg/kg on alternate days | 2 months |
721-152 | Prednisone 1–2 mg/kg/day for 4 weeks, 1 mg/kg alternate days for 4 weeks and taper by 25% each month | 6 months | ||||
Norero et al 23, 1996, Chile | 27 | 29 | Prednisolone—6 weeks each of 60 mg/m2/day and 40 mg/m2 alternate days | 3 months | Prednisolone—4 weeks each of 60 mg/m2/day and 40 mg/m2 alternate days | 2 months |
Bagga et al 24, 1999, India | 23 | 22 | Prednisone—4 weeks each of 2 mg/kg/day, 1.5 mg/kg/day, 1.5 mg/kg alternate days, 1 mg/kg alternate days | 4 months | Prednisone—4 weeks each of 2 mg/kg/day and 1.5 mg/kg alternate days | 2 months |