Group means of lower leg growth rates, serum PICP, PINP, ICTP, and PIIINP, and urine NTx and DPD
| Formoterol and budesonide | Placebo and budesonide | p and t values; 95% confidence interval for the difference1-150 | |
| Lower leg growth rate (mm/week) | 0.39 (0.05) | 0.25 (0.04) | p = 0.02,t = 2.6; 0.03 to 0.26 mm/week |
| PICP (μg/l) | 490 (27) | 447 (28) | p = 0.04,t = 2.2; 2 to 85 μg/l |
| PINP (μg/l) | 582 (40) | 517 (39) | p = 0.004,t = 3.2; 22 to 107 μg/l |
| ICTP (μg/l) | 11.7 (0.5) | 10.5 (0.4) | p = 0.009,t = 2.9; 0.3 to 1.9 μg/l |
| PIIINP (μg/l) | 7.7 (0.6) | 6.4 (0.4) | p = 0.002,t = 3.6; 0.5 to 2.0 μg/l |
| NTx/creatinine (nmol/mmol) | 693 (55) | 566 (54) | p = 0.02,t = 2.4; 18 to 234 nmol/mmol creatinine |
| DPD/creatinine (nmol/mmol) | 16.6 (1.2) | 15.5 (1.0) | p = 0.25,t = 1.2; −0.9 to 3.1 nmol/mmol creatinine |
Serum parameters were measured in 23 asthmatic children (12 boys and 11 girls), and urine parameters in 12 boys and 9 girls during treatment with inhaled formoterol 12 μg and budesonide 100 μg twice daily, and placebo and budesonide 200 μg twice daily.
Results expressed as mean (SEM).
↵1-150 Formoterol and budesonide versus placebo and budesonide.