Examples of hypothalamic neurotransmitters implicated in the control of gonadotrophin releasing hormone (GnRH) neurones and/or in appetite regulation
| Neurotransmitter | GnRH regulation | Appetite regulation |
| γ-Aminobutyric acid | Y (−) | Y (+) |
| Glutamate | Y (+) | Y (+) |
| Neuropeptide Y1-150 | Y (− & +) | Y (+) |
| Galanin | Y (+) | |
| Melanin concentrating hormone | Y (+) | |
| Orexins | Y (+) | |
| Leptin | Y (+) | Y (−) |
| CART1-150 | Y (+) | Y (−) |
| Pro-opiomelanocortin1-150 | Y (+) | Y (−) |
| Melanocyte stimulating hormone | Y (−) | |
| Corticotrophin releasing hormone | Y (−) | |
| Agouti related protein | Y (−) | |
| Urocortin | Y (−) | |
| Glucagon-like peptide-1 | Y (−) |
↵1-150 Factors that may act to mediate the relation between leptin and GnRH secretion.
The sign in parentheses denotes activation/increase or inhibition/decrease.
CART, cocaine and amphetamine regulated transcript.