Patient | Age (years) | Year | Sex | Down's height centile | Capillary TSH | Venous blood | Clinical features | Treated | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TSH | fT4 | Thyroid autoantibodies | |||||||||||||||
Mic | Tg | TP | |||||||||||||||
1 | 15 | 1 | F | 50 | 119 | 132 | 5.2 | > 1/6400 | 1/400 | Pallor, bradycardia, dry skin | Yes | ||||||
2 | 10 | 1 | F | < 5 | 86 | 114 | 7 | > 1/6400 | 1/100 | Cold intolerance, weight gain, dry skin | Yes | ||||||
3 | 12 | 1 | M | 50 | 51 | 108 | 7.7 | > 1/6400 | Neg | Goitre, dry skin | Yes | ||||||
4 | 8 | 1 | M | 75 | 29 | 36.9 | 8.9 | > 1/6400 | 1/1600 | Weight gain | Yes | ||||||
5 | 18 | 1 | M | > 95 | 19 | 11.6 (13.8) | 9.4 (10) | 1/400 | Neg | None | Yes1-150 | ||||||
6 | 14 | 1 | F | 50–75 | 17 | 7.8 (0.04) | 11.8 (29.3) | 1/6400 | 1/400 | None | Yes1-152 | ||||||
7 | 14 | 1 | M | 75–90 | 13 | 12.7 (19.1) | 11.3 (10.5) | > 1/6400 | Neg | None | Yes1-150 | ||||||
8 | 5 | 1 | M | > 95 | 11 | 10.8 (15.7) | 12 (12) | 1/6400 | 1/1600 | None | Yes1-150 | ||||||
9 | 17 | 1 | F | 25–50 | 13 | 10 (7.9) | 9.6 (13.6) | 1/1600 | Neg | Slightly dry skin and hair | No | ||||||
10 | 16 | 1 | M | 5 | 16 | 8.7 (4.7) | 19.7 (12.4) | 1/6400 | Neg | None | No | ||||||
11 | 14 | 2 | F | 50–75 | 14 | 14.8 | 13.1 | > 1000 | Cold intolerance, lethargy | Yes | |||||||
12 | 12 | 2 | F | > 95 | 55 | 79 | 8.7 | 140 | Weight gain | Yes | |||||||
13 | 13 | 2 | M | > 95 | 12 | 40.8 | 8 | 161 | None | Yes | |||||||
14 | 12 | 2 | M | 25–50 | 14 | 7.3 (4.3) | 10.3 (10) | < 50 | None | No | |||||||
15 | 9 | 2 | F | 10–25 | 18 | 9.5 (12.3) | 18 (15.5) | 825 | Juvenile arthritis, no thyroid symptoms | No |
Venous TSH and free T4 values 1 year after screening are given in parenthesis for the eight children who were not initially treated with thyroxine.
Normal values: capillary TSH, < 10 mU/litre; venous TSH, < 5 mU/litre; fT4, 9–27 pmol/litre; Mic and Tg titres, < 1/100, TPO, < 50 IU/ml.
↵1-150 Thyroxine started after retesting one year later.
↵1-152 See text for details.
TSH, thyroid stimulating hormone; fT4, free thyroxine; Mic, microsomal; Tg, thyroglobulin; TPO, thyroid peroxidase; Neg, < 1/100.