Scaled pharmacokinetic parameters of budesonide in 10 preschool children estimated in a non-parametric evaluation assuming identical or different terminal half lives after intravenous infusion and inhalation of budesonide
| Identical terminal half lives | Different terminal half lives | ||||
|---|---|---|---|---|---|
|
Mean (per kg) |
Mean (scaled to 70 kg) |
Mean (per kg) |
Mean (scaled to 70 kg) | ||
| Cl (ml/min) | 29.8 | 1490 | 32.9 | 1645 | |
| Vd(litres) | 5.9 | 411 | 3.2 | 225 | |
| Vss(litres) | 3.1 | 216 | 2.2 | 151 | |
Cl, total clearance; Vd, volume of distribution in terminal phase; Vss, volume of distribution at steady state.