Peak GnRH stimulated concentrations of gonadotropin and sexual steroids in eight children with GDPP due to HH before and during treatment with GnRH-a
| Patient | Sex | Peak LH (IU/L) | Peak FSH (IU/L) | Testosterone (ng/dl) | Oestradiol (pg/ml) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 1 year after treatment | Baseline | 1 year after treatment | Baseline | 1 year after treatment | Baseline | 1 year after treatment | ||||||||||
| 1 | M | 362-150 | 1.7 | 182-150 | < 1 | 2132-150 | < 102-150 | ||||||||||
| 2 | M | 77 | 1.0 | 22 | < 1 | 2752-150 | 232-150 | ||||||||||
| 3 | M | 13 | 0.9 | 4 | < 1 | 342-150 | 222-150 | ||||||||||
| 4 | M | 13 | 1.6 | 2 | < 1 | 2412-150 | 232-150 | ||||||||||
| 5 | M | 372-150 | 23 | 132-150 | 11 | 2512-150 | 5652-150 | ||||||||||
| 6 | F | 522-150 | 1.5 | 92-150 | < 1 | < 102-150 | < 6.8 | ||||||||||
| 7 | F | 23 | 1.5 | 8 | < 1 | 152-150 | < 6.8 | ||||||||||
| 8 | F | 23 | 1.0 | 13 | < 1 | 11 | < 6.8 | ||||||||||
↵2-150 Radioimmunoassay.
Normal pubertal response LH peak after 100 μg of GnRH: for girls, >15 IU/l radioimmunoassay, > 7.0 IU/L immunofluorometric assay; for boys, > 25.5 IU/l radioimmunoassay , > 8.4 IU/l immunofluoremetric assay.
Testosterone (ng/dl): prepubertal levels < 30 ng/dl (radioimmunoassay).