Tacrolimus: major interactions and important side effects6
| Substances that increase concentrations of the drug or are toxic | |
|---|---|
| Macrolides including erythromycin, clarithromycin | |
| Quinolones including ciprofloxacin | |
| Non-steroidal analgesics | |
| Antifungals including amphotericin, fluconazole | |
| Cimetidine, omeprazole | |
| Substances that decrease concentrations of the drug | |
| Anticonvulsants including carbamazepine, phenobarbitone, phenytoin | |
| Rifamycin antibiotics including rifampicin, rifabutin | |
| Main side effects | |
| Neurotoxicity (including alteration of mood and behaviour) | |
| Nephrotoxicity | |
| Induction of diabetes (often transient) | |
| Lymphoproliferative disease (usually Epstein Barr virus induced B cell lymphoma) | |
| Susceptibility to infection | |
| Diarrhoea | |
| Thinning of hair |