Cyclosporin: major interactions and important side effects5
| Substances that increase concentrations of the drug or are toxic | |
|---|---|
| Grapefruit juice | |
| Macrolides including erythromycin, clarithromycin | |
| Antibacterials including trimethoprim, co-trimoxazole | |
| Antifungals including amphotericin, fluconazole | |
| High dose methylprednisolone | |
| Non-steroidal analgesics | |
| Angiotensin converting enzyme inhibitors, calcium channel blockers | |
| Cimetidine | |
| Tacrolimus | |
| Substances that decrease concentrations of the drug | |
| Anticonvulsants including carbamazepine, phenobarbitone, phenytoin | |
| Octreotide | |
| Rifamycins including rifampicin, rifabutin | |
| Griseofulvin | |
| Main side effects | |
| Cosmetic, especially hypertrichosis and gum hypertrophy | |
| Nephrotoxicity | |
| Hypertension | |
| Neurotoxicity (tremor, convulsions) | |
| Susceptibility to infection | |
| Lymphoproliferative disease (usually Epstein Barr virus induced B cell lymphoma) |