Table 1

Lymphocyte surface antigens (per cent of cells)

Cell	Normal	Patient 1	Patient 2	Healthy brother	Mother	Father
T cells
CD3	68–82	74	33	73	69	69
αβ		59	30	67	63	69
γδ		10	3	4	4
CD4	29–55	16	16	46	38	49
CD8	20–36	59	33	30	35	29
CD4:CD8	2:1	0.3	0.5	1.5	1	1.7
B cells
CD19	5–15	75	7	9	7
CD20		11.6	15.9	13.2	8
Natural killer cells
CD16	10–25	14	47	15	18	13
CD56	10–25	26	47	15	18	13
CD57		45	44.5	18	35	26
HLA-DR	7–20	32	23	13	23	19
		98	87	59	73	86
		0.04	13	24	13	7.5