Investigation results in 12 children with focal hypometabolism on FDG PET scan
| Case/sex | Syndromic classification | Age at time of initial FDG PET scan | Initial FDG PET result | Repeat FDG PET result | NAA/choline ratio (CI) | 3D surface MRI | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Visual analysis | Semiquantitative analysis | Visual analysis | Semiquantitative analysis | |||||||||||
| 1/M | De novo LGS (typical) | 8 years 1 month | Left lateral temporal hypometabolism | Left (12%) temporoparietal hypometabolism | Left lateral temporal hypometabolism | Left (15%) lateral temporal hypometabolism | L 1.64 (0.21) R 1.19 (0.13) | – | ||||||
| 2/F | Infantile spasms developing LGS (atypical) | 11 years 1 month | Right temporal hypometabolism | Right (15%) temporal hypometabolism | Right temporal hypometabolism | Right (6%) temporal hypometabolism | – | – | ||||||
| 3/F | Infantile spasms Developing LGS (typical) | 6 months | Left fronto- temporoparietal hypometabolism | Left (18%) fronto- temporoparietal hypometabolism | Normal | Left (7%) fronto- temporoparietal hypometabolism | – | – | ||||||
| 4/M | Infantile spasms developing LGS (typical) | 10 years 5 months | Left parietal hypometabolism | Left (10/15%) temporoparietal hypometabolism | Left parietal hypometabolism | Left (16%) parietal hypometabolism | L 1.17 (0.07 ) R 1.27 ( 0.08) | – | ||||||
| 5/M | Myoclonic astatic epilepsy (atypical) | 9 years 10 months | Left temporoparietal hypometabolism | Left (10%) temporoparietal hypometabolism | Left temporoparietal hypometabolism | Left and right areas of hypometabolism | L 2.13 (0.11) R 1.61 (0.12) | Normal | ||||||
| 6/M | Severe myoclonic epilepsy of infancy (typical) | 10 years 0 months | Right temporal hypometabolism | Right (13%) medial temporal hypometabolism | Right temporal hypometabolism | Right (7%) lateral temporal hypometabolism | – | Normal | ||||||
| 7/M | Severe myoclonic epilepsy of childhood (typical) | 9 years 9 months | Right temporal hypometabolism | Right (>15%) temporal hypometabolism | Not repeated | Not repeated | – | Normal | ||||||
| 8/F | Myoclonic astatic epilepsy (atypical) | 12 years 2 months | Right temporoparietal hypometabolism | Right (20%) temporal hypometabolism | Right temporoparietal hypometabolism | Right (22%) temporal hypometabolism | – | Normal | ||||||
| 9/F | Unclassified | 2 years 3 months | Left anterior temporal hypometabolism | Left (15/18%) anteriomedial temporal hypometabolism | Left anterior temporal hypometabolism | Left (39%) anterior temporal hypometabolism | L 1.02 (0.06) R 1.37 (0.14) | Normal | ||||||
| 10/M | Unclassified | 7 years 11 months | Right anterior temporal hypometabolism | Right (35%) anteriomedial temporal hypometabolism | Right anterior temporal hypometabolism | Right (35/15%) anteriomedial temporal hypometabolism | L 1.55 (0.11) R 0.93 (0.07) | Smaller right temporal lobe | ||||||
| 11/M | Unclassified | 3 years 10 months | Right temporal hypometabolism | Right (20%) temporal hypometabolism | Right temporal hypometabolism | Right (14%) temporal hypometabolism | – | – | ||||||
| 12/F | Unclassified | 5 years 0 months | Left temporal hypometabolism | Left (19%) temporal hypometabolism | Left temporal hypometabolism | Left (27%) temporal hypometabolism | L 0.77 (0.09) R 1.15 (0.11) | Normal | ||||||
LGS, Lennox-Gastaut syndrome; L, left; R, right.