Studies that have specifically sought optical toxicity
| Reference | Patients (n) | Age range | Method of evaluation | Dose of ethambutol (mg/kg/day) | Duration of treatment (months) | Length of follow up (months) | Number with toxicity |
|---|---|---|---|---|---|---|---|
| 24 | 47 | 3–13 years | Visual evoked responses | 20 | 12 | 15–18 | 0 |
| 25 | 36 | 4 months to 16 years | Acuity/field/colour | 25 then 15 | 6 then 18 | 24–48 | 0 |
| Fox2-150 | 45 | 1–15 years | Acuity/field/colour | 15–25 | 9–18 | 9–18 | 0 |
| 26 | 30 | 4–5 years | Acuity/field/colour | 25 twice a week | 6 | 6 | 0 |
| 27 | 27 | 5–15 years | Acuity/field/colour | 20 | 2–24 | 12–36 | 0 |
| 28 | 6 | 9–16 years | Computerised visual field examination | 20 | 12 | 9 | 0 |
↵2-150 Fox W, unpublished data quoted inTubercle 1986;67:27.