ANCA results in 12 patients with Wegener’s granulomatosis
| Case | ANCA IIF pattern | Titre (in ELISA units) | Antigenic specificities | Concomitant clinical parameters | |||||
|---|---|---|---|---|---|---|---|---|---|
| Crude ANCA IgG (control < 4.1) | Crude ANCA IgM (control < 9.6) | ESR (mm/h) | Hb (g/l) | WBC (× 109/l) | Platelets (× 109/l) | ||||
| 1 | P-ANCA | 10.0 | 256.0 | MPO-IgG, MPO-IgM, Cath-IgG, Elas-IgG | 88 | 93 | 9.6 | 344 | |
| 2 | Negative | 1.8 | 13.8 | PR3-IgG, Lact-IgG, Cath-IgM | 48 | 98 | 19.7 | 1098 | |
| 3 | C-ANCA | 20.0 | 11.8 | PR3-IgG, MPO-IgM, Cath-IgM | 70 | 66 | 9.6 | 447 | |
| 4 | C-ANCA | 8.0 | 2.6 | MPO-IgG, Lact-IgG, Cath-IgG, Elas-IgG | 38 | 123 | 9.4 | 470 | |
| 5 | Negative | 5.5 | 5.2 | Titre within control range | 83 | 126 | 9.7 | 385 | |
| 6 | C-ANCA | 4.8 | 11.0 | MPO-IgM, Cath-IgM | 90 | 69 | 14.0 | 375 | |
| 7 | C-ANCA | 43.6 | 36.0 | PR3-IgG, MPO-IgM, Cath-IgM | 100 | 79 | 6.3 | 957 | |
| 8 | Negative | 1.9 | 0.5 | Titre within control range | 96 | 78 | 8.6 | 425 | |
| 9 | C-ANCA | 0.5 | 35.7 | Cath-IgG, Cath-IgM | 56 | 110 | 6.5 | 395 | |
| 10 | C-ANCA | 10.0 | 0.7 | PR3-IgG | 40 | 91 | 14.6 | 375 | |
| 11 | Negative | 4.2 | 13.6 | MPO-IgM, Lact-IgG, Cath-IgG, Cath-IgM | 50 | 121 | 23.6 | 607 | |
| 12 | Negative | 3.0 | 8.2 | Titre within control range | 40 | 120 | 24.3 | 1033 | |
P-ANCA, perinuclear pattern; C-ANCA, cytoplasmic pattern; MPO, antimyeloperoxidase titre; Cath, anticathepsin G titre; Lact, antilactoferrin titre; Elas; antielastase titre; PR3, antiproteinase 3 titre; ESR, erythrocyte sedimentation rate; Hb, haemoglobin; WBC total white blood cell count.