Group A | Group B | p value | |
---|---|---|---|
Serum peak on day 1 (mg/l) | 13.2 (7.1) | 42.5 (11.2) | < 0.001 |
Serum peak on day 14 (mg/l) | 12.4 (3.9) | 39.4 (20) | < 0.001 |
Serum trough on day 1 (mg/l) | 1.1 (0.8) | 0.3 (0.2) | < 0.01 |
Serum trough on day 14 (mg/l) | 0.9 (0.5) | 0.4 (0.3) | < 0.01 |
Total clearance (ml/h/kg) | 3.73 (1.37) | 4.73 (2.43) | 0.4 |
Volume of distribution (l/kg) | 0.54 (0.88) | 0.97 (0.44) | 0.6 |
Area under the curve (mg.h/l) | 121.5 (42) | 98.6 (32.5) | 0.6 |
Group A, thrice daily infusions of tobramycin; group B, once daily infusions of tobramycin. Values are mean (SD).