Basal growth hormone (μg/l), IGF-I (nmol/l), and IGFBP-3 (mg/l) concentrations in 17 spina bifida patients with hydrocephalus and 73 healthy controls. The values are mean (95% confidence interval)
| Patients | Controls | p Value | |
|---|---|---|---|
| Prepubertal | (n=6) | (n=32) | |
| Age (years) | 7.0 (4.6 to 9.3) | 8.0 (7.3 to 8.8) | 0.17 |
| Basal growth hormone | 1.0 (−0.70 to 2.8) | 2.1 (0.8 to 3.5) | 0.81 |
| IGF-I | 5.2 (3.1 to 7.4) | 12.4 (10.8 to 13.9) | 0.001 |
| IGFBP-3 | 1.9 (1.2 to 2.7) | 3.7 (3.4 to 4.0) | 0.001 |
| Pubertal | (n=11) | (n=41) | |
| Age (years) | 15.1 (12.8 to 17.4) | 15.0 (14.2 to 15.8) | 0.96 |
| Basal growth hormone | 2.7 (−0.87 to 6.2) | 8.5 (5.6 to 11.3) | 0.02 |
| IGF-I | 15.9 (10.8 to 21.0) | 21.3 (19.1 to 23.6) | 0.03 |
| IGFBP-3 | 4.1 (2.6 to 5.5) | 4.3 (4.0 to 4.6) | 0.33 |