Clinical features of 14 children with ACTH secreting pituitary tumours (13 with Cushing’s disease and 1 with Nelson’s syndrome)
| Patient No | Sex | Diagnosis | Length of history (years) | Age at operation (years) | Height (cm) | Height SD score | Bone age (years) | Weight gain | Cushingoid appearance1-150 | Acne | Hirsutism | Symptoms and signs | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood pressure | Pubertal development (ratings) | ||||||||||||||||||||||||
| 1 | F | Cushing’s disease | 1.0 | 15.5 | 156.0 | −1.1 | Not recorded | + | + | + | + | 120/80 | Concordant (B2, P2, A2, M0) | ||||||||||||
| 2 | F | Cushing’s disease | 3.0 | 13.1 | 140.2 | −2.2 | 11.0 | + | + | − | − | 120/95(↑) | Concordant (B3, P2, A2, M0) | ||||||||||||
| 3 | F | Cushing’s disease | 4.5 | 16.3 | 154.1 | −1.5 | 15.0 | + | + | − | − | 120/80 | Concordant (B5, P5, A3, M1) | ||||||||||||
| 4 | F | Cushing’s disease | 4.0 | 13.2 | 138.6 | −2.5 | 12.5 | + | + | + | + | 120/70 | Concordant (B3, P4, A3, M0) | ||||||||||||
| 5 | F | Cushing’s disease | 3.0 | 11.8 | 135.7 | −1.8 | 11.0 | + | + | + | + | 110/80 | Discordant (B2, P3, A3, M0) | ||||||||||||
| 6 | M | Cushing’s disease | 1.0 | 14.8 | 160.0 | −1.0 | Not recorded | + | + | + | + | 120/90(↑) | Concordant (G5, P5, A3, 20,20) | ||||||||||||
| 7 | M | Cushing’s disease | 3.0 | 14.9 | 146.8 | −2.6 | 13.0 | + | + | + | + | 110/60 | Discordant (G5, P5, A3, 08,08) | ||||||||||||
| 8 | M | Cushing’s disease | 4.0 | 16.2 | 147.0 | −3.6 | 14.4 | + | + | − | − | 130/80 | Delayed (G1, P1, A1, 02,02) | ||||||||||||
| 9 | M | Cushing’s disease | 1.5 | 12.8 | 143.2 | −1.3 | Not recorded | + | + | + | + | 140/80 | Discordant (G3, P4, A3, 03,03) | ||||||||||||
| 10 | M | Cushing’s disease | 1.5 | 14.1 | 145.0 | −2.2 | 13.0 | + | + | + | + | 120/75 | Concordant (G2, P2, A2, 03,03) | ||||||||||||
| 11 | M | Cushing’s disease | 2.0 | 16.2 | 159.7 | −1.9 | 15.6 | + | + | + | + | 120/80 (on treatment) | Concordant (G3, P4, A3, 08,08) | ||||||||||||
| 12 | M | Cushing’s disease | 4.0 | 14.3 | 147.7 | −2.0 | 15.9 | + | + | + | + | 145/120 (↑) | Discordant (G2, P5, A2, 04,04) | ||||||||||||
| 131-151 | M | Cushing’s disease/MEN type 1 | 0.5 | 8.7 | 129.6 | −0.4 | 7.8 | + | + | − | − | 135/90 (↑) | Prepubertal (G1, P2, A1, 02,02) | ||||||||||||
| 141-152 | M | Nelson’s syndrome | 0.8 | 16.9 | 164.1 | −1.6 | Not recorded | − | − | − | − | 110/70 | Concordant (G5, P5, A3, 15,15) | ||||||||||||
↵1-150 Moon face, buffalo hump, truncal obesity, and striae.
↵1-151 Patient with an extensive family history of multiple endocrine neoplasia (MEN) type 1.
↵1-152 Patient presented originally with Cushing’s disease aged 12 years and underwent bilateral adrenalectomies elsewhere. Represented with skin hyperpigmentation and headaches.