Author | No of patients | Aetiology of vitamin B-12 deficiency | Age at diagnosis (months) | Haemoglobin (< 100 g/l) | Neurological symptoms | Comatose | Neurodevelopment at follow up |
---|---|---|---|---|---|---|---|
Jadhav et al 5 | 6 | 4 MPA, 2 vegan | 7-12 | 6/6 | 6/6 | 5/6 | No follow up |
Pearson and Turner10 | 1 | MPA | 32 | 1/1 | 1/1 | 1/1 | Abnormal at 6 years |
Wighton et al 7 | 1 | Vegan | 9 | 1/1 | 1/1 | 1/1 | Abnormal at 12 years |
Higginbottom et al 4 | 1 | Vegan | 6 | 1/1 | 1/1 | 1/1 | No follow up |
Close20 | 1 | Vegan | 12 | 1/1 | 1/1 | 1/1 | No follow up |
Sklar9 | 1 | Vegan | 7 | 1/1 | 1/1 | — | Normal at 13 months |
Stollhoff and Schulte6 | 1 | Vegan | 14 | 1/1 | 1/1 | 1/1 | Abnormal at 26 months |
McPhee et al 14 | 1 | MPA | 5 | 1/1 | 1/1 | 0/1 | Normal at 8 years |
Kühne et al 8 | 1 | Vegan | 9 | 1/1 | 1/1 | 1/1 | Normal at 13 months |
Michaud et al 12 | 2 | 1 MPA, 1 vegan | 2 | 0/2 | 0/2 | 0/2 | Normal at 14 months and 2 years |
Graham et al 3 | 6 | 3 MPA, 3 vegan | 8-15 | 4/6 | 6/6 | 6/6 | 2 normal at 9 and 10 years, 2 abnormal at 4 and 5 years |
Almadan et al 2 | 2 | Vegan | 5, 24 | 2/2 | 2/2 | 2/2 | No follow up |
Grange and Finlay13 | 1 | Gastric bypass | 10 | 1/1 | 1/1 | 1/1 | Normal at 12.5 months |
Our patient | 1 | Vegan | 14 | 1/1 | 1/1 | 1/1 | Abnormal at 26 months |
MPA = maternal penicious anaemia; vegan = strictly vegetarian (vegan) diet of the mother; gastric bypass = maternal gastric bypass surgery.