RT Journal Article SR Electronic T1 P28 Cerebral malformations diagnosed and supervised in paediatric clinic ii, craiova, romania JF Archives of Disease in Childhood JO Arch Dis Child FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health SP A45 OP A45 DO 10.1136/archdischild-2017-313273.116 VO 102 IS Suppl 2 A1 Laura Daniela Marinau A1 Ileana Puiu A1 Ileana Petrescu A1 Cristina Singer A1 Simona Raciula YR 2017 UL http://adc.bmj.com/content/102/Suppl_2/A45.1.abstract AB The disruption of brain ontogeny phases leads to major early malformations, such as forebrain, anencephaly. Cephalic malformations are most commonly hydrocephalus and microcephaly.The authors have analysed data collected from the medical observation sheets of Paediatrics Clinic II, Craiova, for patients hospitalised between 2007–2015, with diagnoses of CNS malformations.Results there were 87 patients with brain malformations in the study. The types of defects noted: microcephaly: 46; hydrocephalus: 21; pellucida/arachnoid septum cyst : 3 and 3; cave of septum pellucidum: 1; right cerebral hemisphere atrophy-1; agenesis of the corpus callosum-1, Dandy Walker syndrome-1; periventricular cysts-1; mirror movement disorder(splitting cerebral) −1, holoprosencephaly-1. The outcome was lethal to 12 children in the reviewed period, others were transferred, but 7 patients with myelomeningocele and hydrocephalus were operated successfully.Surgical treatments improved survival rate in case of congenital cranial defects, as demonstrated by this study.