@article {Alshaikh957, author = {Nahla Alshaikh and Andreas Brunklaus and Tracey Davis and Stephanie A Robb and Ros Quinlivan and Pinki Munot and Anna Sarkozy and Francesco Muntoni and Adnan Y Manzur}, title = {Vitamin D in corticosteroid-na{\"\i}ve and corticosteroid-treated Duchenne muscular dystrophy: what dose achieves optimal 25(OH) vitamin D levels?}, volume = {101}, number = {10}, pages = {957--961}, year = {2016}, doi = {10.1136/archdischild-2015-308825}, publisher = {BMJ Publishing Group Ltd}, abstract = {Aim Assessment of the efficacy of vitamin D replenishment and maintenance doses required to attain optimal levels in boys with Duchenne muscular dystrophy (DMD).Method 25(OH)-vitamin D levels and concurrent vitamin D dosage were collected from retrospective case-note review of boys with DMD at the Dubowitz Neuromuscular Centre. Vitamin D levels were stratified as deficient at \<25 nmol/L, insufficient at 25{\textendash}49 nmol/L, adequate at 50{\textendash}75 nmol/L and optimal at \>75 nmol/L.Result 617 vitamin D samples were available from 197 boys (range 2{\textendash}18 years){\textemdash}69\% from individuals on corticosteroids. Vitamin D-na{\"\i}ve boys (154 samples) showed deficiency in 28\%, insufficiency in 42\%, adequate levels in 24\% and optimal levels in 6\%. The vitamin D-supplemented group (463 samples) was tested while on different maintenance/replenishment doses. Three-month replenishment of daily 3000 IU (23 samples) or 6000 IU (37 samples) achieved optimal levels in 52\% and 84\%, respectively. 182 samples taken on 400 IU revealed deficiency in 19 (10\%), insufficiency in 84 (47\%), adequate levels in 67 (37\%) and optimal levels in 11 (6\%). 97 samples taken on 800 IU showed deficiency in 2 (2\%), insufficiency in 17 (17\%), adequate levels in 56 (58\%) and optimal levels in 22 (23\%). 81 samples were on 1000 IU and 14 samples on 1500 IU, with optimal levels in 35 (43\%) and 9 (64\%), respectively. No toxic level was seen (highest level 230 nmol/L).Conclusions The prevalence of vitamin D deficiency and insufficiency in DMD is high. A 2-month replenishment regimen of 6000 IU and maintenance regimen of 1000{\textendash}1500 IU/day was associated with optimal vitamin D levels. These data have important implications for optimising vitamin D dosing in DMD.}, issn = {0003-9888}, URL = {https://adc.bmj.com/content/101/10/957}, eprint = {https://adc.bmj.com/content/101/10/957.full.pdf}, journal = {Archives of Disease in Childhood} }