PT  - JOURNAL ARTICLE
AU  - J Chemli
AU  - S Chaieb
AU  - S Ketata
AU  - M Mokni
AU  - N Arifa
AU  - A Harbi
TI  - CYTOMEGALOVIRUS AND HELICOBACTER PYLORI CO-INFECTION IN A CHILD WITH MéNéTRIER’S DISEASE
DP  - 2008 Nov 01
TA  - Archives of Disease in Childhood
PG  - ps120--ps120
VI  - 93
IP  - Suppl 2
4099  - http://adc.bmj.com/content/93/Suppl_2/ps120.short
4100  - http://adc.bmj.com/content/93/Suppl_2/ps120.full
SO  - Arch Dis Child2008 Nov 01; 93
AB  - Ménétrier’s disease is an uncommon disease in childhood characterized by enlarged gastric rugal folds and gastric mucosal thickening and hypoproteinemia secondary to a protein-losing gastroenteropathy. In this report we present the second case of Ménétrier’s disease in a child with co-infection of cytomegalovirus (CMV) and Helicobacter pylori (H. pylori).Case report A 12 month-old boy was admitted with a two week history of oedema of the face and extremities associated with vomiting. Urine analyses were normal. Protein losing enteropathy was confirmed by laboratory investigations: hypoalbuminemia, hypoproteinemia and eleved fecal alpha1 antitrypsin. Diagnosis of Ménétrier’s disease was suspected by the presence of thick gastric folds on gastric ultrasound and gastrointestinal endoscopy and confirmed by histological study. Aetiological investigations revealed co-infection of CMV and H. pylori. After the eradication therapy against H. pylori, we observed clinical, biochemical and ultrasonographic resolution of the disease.Conclusion Intractable Ménétrier’s disease with CMV infection may associate with H. pylori infection. In such a case, eradication therapy of H. pylori may contribute to clinical resolution.