PT  - JOURNAL ARTICLE
AU  - K Panula
AU  - S Rautava
AU  - E Löyttyniemi
AU  - S Salminen
AU  - E Isolauri
TI  - PO-1027 The Impact Of Neonatal Antibiotic Exposure On Atopic Sensitisation By The Age Of 12 Months
AID  - 10.1136/archdischild-2014-307384.1643
DP  - 2014 Oct 01
TA  - Archives of Disease in Childhood
PG  - A586--A586
VI  - 99
IP  - Suppl 2
4099  - http://adc.bmj.com/content/99/Suppl_2/A586.2.short
4100  - http://adc.bmj.com/content/99/Suppl_2/A586.2.full
SO  - Arch Dis Child2014 Oct 01; 99
AB  - Background and aims Empirical antibiotic therapy is common in the neonatal period but often discontinued due to the lack of evidence of bacterial infection. Early antibiotic exposure may disturb microbial colonisation and immune maturation and thus increase the risk of immune-mediated diseases in later life. We investigated the long-term immune effects of early antibiotic exposure in neonates with or without evidence of infection. Methods Altogether 622 neonates from ongoing allergy prevention studies underwent skin prick testing at the age of 12 months. Exposure to antibiotics commenced during the first 72 h of life was categorised as follows: no exposure, brief empirical exposure (less than 5 days) or therapy for documented infection (≥5 days). Outcomes were analysed by logistic regression. Results Brief neonatal antibiotic exposure was associated with lower risk of prick test positivity (Table 1). The effect remained statistically significant after adjusting for potential confounding factors (Table 2). Conclusions Brief antibiotic exposure during the first days of life without concomitant infectious disease appears to impact immune development. View this table:Abstract PO-1027 Table 1 Prevalence of positive skin prick test by antibiotic exposure View this table:Abstract PO-1027 Table 2 Logistic regression model for skin prick test positivity