PT  - JOURNAL ARTICLE
AU  - J-B Hwang
AU  - S M Sohn
AU  - A S Kim
TI  - Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome
AID  - 10.1136/adc.2008.143289
DP  - 2009 Jun 01
TA  - Archives of Disease in Childhood
PG  - 425--428
VI  - 94
IP  - 6
4099  - http://adc.bmj.com/content/94/6/425.short
4100  - http://adc.bmj.com/content/94/6/425.full
SO  - Arch Dis Child2009 Jun 01; 94
AB  - Objectives: To determine tolerance rates to cow’s milk and soy and to suggest guidelines for follow-up oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).Methods: The authors analysed the data of 23 patients with infantile FPIES who underwent two or more FU-OFCs and were followed up until over 2 years of age. The first FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow’s milk (n = 11) or soy (n = 12) challenge starting groups. Second and third FU-OFCs were performed at 2-month intervals in a crossed and switched-over manner.Results: Tolerance rates to cow’s milk and soy were 27.3% and 75.0% at 6 months of age, 41.7% and 90.9% at 8 months and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow’s milk and soy intolerance at age 20 and 14 months.Conclusions: In infantile FPIES, the first FU-OFC should be performed with soy at 6–8 months of age and cow’s milk FU-OFC should be conducted at over 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.