RT Journal Article
SR Electronic
T1 Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis.
JF Archives of Disease in Childhood
JO Arch Dis Child
FD BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health
SP 1114
OP 1120
DO 10.1136/adc.61.11.1114
VO 61
IS 11
A1 M M Brett
A1 A T Ghoneim
A1 J M Littlewood
YR 1986
UL http://adc.bmj.com/content/61/11/1114.abstract
AB Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20,500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis.