Insulin prophylaxis in individuals at high risk of type I diabetes

Lancet. 1993 Apr 10;341(8850):927-8. doi: 10.1016/0140-6736(93)91215-8.

Abstract

Prevention of type I diabetes is now a practical goal thanks to the ability to define confidently a high-risk group and the success of preventive strategies in animal models. We describe here a pilot trial of low-dose insulin to prevent diabetes in relatives of patients with type I diabetes.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Autoantibodies / blood
  • Blood Glucose / analysis
  • Child
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diabetes Mellitus, Type 1 / epidemiology
  • Female
  • Follow-Up Studies
  • Glucose Tolerance Test
  • Humans
  • Infusions, Intravenous
  • Injections, Subcutaneous
  • Insulin / administration & dosage
  • Insulin / pharmacology
  • Insulin / therapeutic use*
  • Insulin Antibodies / blood
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / immunology
  • Islets of Langerhans / metabolism
  • Life Style
  • Life Tables
  • Male
  • Mass Screening
  • Pedigree
  • Pilot Projects
  • Primary Prevention / methods
  • Primary Prevention / standards*
  • Risk Factors
  • Treatment Outcome

Substances

  • Autoantibodies
  • Blood Glucose
  • Insulin
  • Insulin Antibodies