Serum antibodies to Pseudomonas aeruginosa in cystic fibrosis

Arch Dis Child. 1986 Nov;61(11):1114-20. doi: 10.1136/adc.61.11.1114.

Abstract

Serum IgG antibodies to Pseudomonas aeruginosa cell surface antigens were determined by enzyme linked immunosorbent assay. Titres in patients without cystic fibrosis were low (140-235). Those in patients with cystic fibrosis who were chronically infected by P. aeruginosa were very high (1100-20,500), while patients who grew the organism intermittently had lower titres (160-4400). Longitudinal studies showed that raised titres were observed at a very early stage of infection. High titres were associated with a poor clinical state, while low titres were associated with a better clinical state in both chronic and intermittently infected patients with cystic fibrosis. These results suggest that this test is a specific and sensitive measure of the severity and progress of the different stages of pulmonary infection by P. aeruginosa in patients with cystic fibrosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / analysis*
  • Child
  • Child, Preschool
  • Cystic Fibrosis / complications
  • Cystic Fibrosis / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / analysis
  • Infant
  • Lung Diseases / complications
  • Lung Diseases / diagnosis
  • Male
  • Pseudomonas Infections / complications
  • Pseudomonas Infections / diagnosis
  • Pseudomonas aeruginosa / immunology*

Substances

  • Antibodies, Bacterial
  • Immunoglobulin G