Hemodynamic profiles of patients with dengue hemorrhagic fever during toxic stage: an echocardiographic study

Intensive Care Med. 2003 Apr;29(4):570-4. doi: 10.1007/s00134-003-1671-9. Epub 2003 Feb 21.

Abstract

Objective: To study left ventricular performance and hemodynamic abnormalities during different stages of dengue hemorrhagic fever (DHF).

Design and setting: Observational study in a tertiary medical school hospital.

Patients: Twenty-four patients with serologically confirmed diagnosis of dengue virus infection and DHF according to the WHO criteria.

Methods: Echocardiography was performed during toxic, convalescent stages and at least 2 weeks after discharge (recovery). Left ventricular ejection fraction, rate-corrected velocity of circumferential fiber shortening adjusted for end-systolic meridional wall stress (VCFC/ESS) Z score, end-diastolic volume Z score, cardiac index, heart rate, mean arterial pressure, and total systemic vascular resistance (SVR) were compared between different stages of DHF.

Results: Ejection fraction and VCFC/ESS were significantly lower during the toxic stage than after recovery. End-diastolic volume was low during toxic stage and returned to normal during convalescence and recovery. Cardiac index was low during the toxic stage due to decreased preload (low end-diastolic volume) and depressed left ventricular ejection fraction. Cardiac index remained subnormal during convalescence due to sinus bradycardia. Wide variation in heart rate during toxic stage resulted in a small, nonsignificant increase compared to recovery. With treatment, heightened SVR resulted in relatively normal mean arterial pressure throughout the course of the illness.

Conclusions: The mechanism of decreased cardiac output during toxic stage of DHF is complex. Decreased preload is accompanied by decreased left ventricular performance, and possibly a subnormal heart rate response in some patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Cardiac Volume
  • Child
  • Echocardiography*
  • Female
  • Hemodynamics*
  • Humans
  • Male
  • Severe Dengue / diagnostic imaging*
  • Severe Dengue / physiopathology*
  • Stroke Volume
  • Ventricular Dysfunction, Left / diagnostic imaging*
  • Ventricular Dysfunction, Left / physiopathology*