Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Regular ArticleThe role of long-chain polyunsaturated fatty acids in infant cognitive development
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Metabolomic and lipidomic characterization of an X-chromosome deletion disorder in neural progenitor cells by UHPLC-HRMS
2021, Journal of Mass Spectrometry and Advances in the Clinical LabCitation Excerpt :The downregulation of intrinsic negative curvature lipid metabolism in the X-deletion group corresponds to the prior result of lower PE lipids compared to control. Studies have indicated that long-chain PUFAs play an essential role in normal brain growth and cognitive development in infants [51–53]. The dysregulation of PUFAs in X-deletion samples could be a critical element in brain function in this patient and for X-deletion syndrome.
Mercury, methylmercury and long-chain polyunsaturated fatty acids in selected fish species and comparison of approaches to risk-benefit analysis
2020, Food and Chemical ToxicologyCitation Excerpt :Fish are also an important dietary source of long-chain ω-3 polyunsaturated fatty acids (LCω3PUFA), particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Maternal intake of fish low in MeHg and high in DHA and EPA has been associated with improved neurodevelopment in offspring (Cohen et al., 2005; Daniels et al., 2004; Willatts and Forsyth, 2000). The current study investigated the t-Hg, MeHg and DHA and EPA content of commercially important New Zealand fish species (FAO, 2019).
The Kansas University DHA Outcomes Study (KUDOS) clinical trial: Long-term behavioral follow-up of the effects of prenatal DHA supplementation
2019, American Journal of Clinical NutritionExecutive function in the first three years of life: Precursors, predictors and patterns
2016, Developmental ReviewCitation Excerpt :One candidate for such a component is docosahexaenoic acid (DHA) – a form of long-chain polyunsaturated fatty acids that occurs naturally in human breast milk. Supplementation of infant formula with DHA has been tentatively linked to improved information processing in infants (O'Connor et al., 2001; Willatts & Forsyth, 2000; but see also Auestad et al., 2001); it is therefore feasible that differences in infant diet (for example in the duration of exclusive breastfeeding) might lead to different growth rates in processing speed, although considerable further research is required. It should also be noted that the predictive value of differences in infant information processing to later EF performance is small, accounting for only 9–19% of variance in the study of Rose et al. (2012).
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Correspondence to: P. Willatts PhD, Department of Psychology, University of Dundee, Dundee DD1 4HN, UK. Tel.: 01382 344623/344618; Fax: 01382 229993; E-mail: [email protected]