Abstract
Allergic rhinitis is a common disease of complex inheritance and is characterised by mucosal inflammation caused by allergen exposure. The genetics of closely related phenotypes such as asthma, atopy and to some extend atopic dermatitis has attracted attention in recent years. Genetic reports of allergic rhinitis on the contrary have as yet been most sparse. To identify candidate regions holding genes for allergic rhinitis we performed a total genome-scan on affected sib-pair families. From 100 Danish sib-pair families selected for allergy, families containing sib-pairs matching a phenotype definition of both clinical allergic rhinitis and confirmed specific allergy were chosen. Thirty-three affected sib-pair families qualified for the scan that was undertaken using 446 microsatellite markers. Non-parametric linkage results were obtained from MAPMAKER/SIBS computer program. The study revealed one major candidate region on chromosome 4q24-q27 (LOD=2.83) and eight minor candidate regions 2q12-q33, 3q13, 4p15-q12, 5q13-q15, 6p24-p23, 12p13, 22q13, and Xp21 (LOD=1.04–1.63) likely to contain susceptibility genes for allergic rhinitis. Our findings did not support a previous report of linkage of allergic rhinitis to chromosome 12q14-q24 but they added positive evidence to the asthma and atopy candidate regions 2q33 and 6p23. Further identification of the specific genes involved in allergic rhinitis will give opportunities for improved diagnosis and treatment.
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Acknowledgements
We thank patients and their families for participating in the ITA-project. The enthusiastic co-operation by the staff of the five Danish outpatient allergy clinics in Aalborg, Viborg, Herning and Aarhus during recruitment of the allergy families is greatly acknowledged. The project has been funded by Ville Heises Fund; the Faculty of Health Sciences, Aarhus University; Hørslev Fund; Danish Lung Association; Danish Allergy Research Centre; The Danish Asthma-Allergy Association, Mimi and Victor Larsen's Fund and ALK Abello Denmark.
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Haagerup, A., Bjerke, T., Schøitz, P. et al. Allergic rhinitis – a total genome-scan for susceptibility genes suggests a locus on chromosome 4q24-q27. Eur J Hum Genet 9, 945–952 (2001). https://doi.org/10.1038/sj.ejhg.5200753
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DOI: https://doi.org/10.1038/sj.ejhg.5200753
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