Transactions of the Twenty-Fourth Annual Meeting of the Society for Maternal-Fetal MedicinePrenatal exposure to binge drinking and cognitive and behavioral outcomes at age 7 years
Section snippets
Subjects
All mothers in this study received prenatal care at Wayne State University clinics and participated in a larger institutional review board–approved pregnancy study. The pregnancy study enrolled 600+ women annually on the basis of a strategy to oversample alcohol-exposed pregnancies. The women who enrolled were interviewed at each prenatal visit, and the infants were evaluated neonatally. Urine was collected at visits and delivery as clinically indicated.
Children who were delivered from
Sample
Of the 665 eligible child-parent dyads, 94% of the families (626 families) agreed to participate; however, 40 of the families (6%) missed multiple appointments. These 40 families and those families with significant missing data (n = 30; 4%) were eliminated from further analysis. The remaining sample consisted of 556 families (84% retention rate). Although teacher compliance was high (>90%), this missing data reduced the sample for behavioral outcome analyses to 499. The children, all of whom were
Comment
Prenatal alcohol exposure was significantly related to both decreased IQ score and increased behavior problems in this large sample of black first grade students. Children who were exposed to binge drinking prenatally, regardless of the amount of overall pregnancy exposure, had significantly lower verbal IQ scores and significantly higher levels of teacher-reported delinquent behavior compared with the remaining children, even after control for other prenatal exposures and postnatal
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Cited by (0)
Supported by National Institute of Drug Abuse R01 DA08524 (V.D-B.).
Presented at the Twenty-Fourth Annual Meeting of the Society for Maternal Fetal Medicine, New Orleans, LA, February 2-7, 2004.