ArticlesIntensification of treatment and survival in all children with lymphoblastic leukaemia: results of UK Medical Research Council trial UKALL X☆
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Developing a conceptual model of teenage and young adult experiences of cancer through meta-synthesis
2013, International Journal of Nursing StudiesCitation Excerpt :A recent trend to extend the upper age eligibility criteria of some paediatric treatment protocols to allow older teenagers and young adults to be included. This is in response to evidence of superior survival for young people treated on paediatric regimes (Boissel et al., 2003; Chessells et al., 1995; Hallbook et al., 2006). An example of this is the paediatric Acute Lymphoblastic Leukaemia protocol UKALL 2003 where reported symptom severity was greater for young people, for example avascular necrosis.
Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: A randomized study by the Children's Oncology Group (POG 9404)
2011, BloodCitation Excerpt :Methotrexate, a folate analog which inhibits intracellular folate-requiring enzymes, has been a vital component of successful ALL treatment regimens regardless of immunophenotype. Doses have ranged from 20 mg/m2 given orally on a weekly schedule to 33.6 g/m2 given by 24-hour intravenous infusion.14,19,23-26 The optimal dose and route of administration are still debated.
Early Relapse in ALL Is Identified by Time to Leukemia in NOD/SCID Mice and Is Characterized by a Gene Signature Involving Survival Pathways
2011, Cancer CellCitation Excerpt :Leukemia cell clearance in response to steroid treatment is evaluated and has been used as a prognostic marker for almost 20 years, demonstrating inferior survival for patients responding poorly to prednisone (Gajjar et al., 1995; Riehm et al., 1987; Schrappe et al., 1998, 2000a, 2000b). In addition, detection of residual leukemia cells at submicroscopic levels after remission induction therapy (minimal residual disease, MRD) qualifies for HR treatment (Chessells et al., 1995; Conter et al., 2010; Flohr et al., 2008; Steinherz et al., 1996; van Dongen et al., 1998). Early identification of patients with high risk for relapse has led to improved outcome.
Pediatric Leukemias and Lymphomas
2010, Leibel and Phillips Textbook of Radiation Oncology, Third Edition
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Members during MRC UKALL X listed at end of paper