Original article
Apnea associated with respiratory syncytial virus infection in young infants1

https://doi.org/10.1016/S0022-3476(77)80697-5Get rights and content

The hospital charts of 274 infants under 6 months of age with culture-proved respiratory syncytial virus infections were reviewed. Fifty-six infants (20.4%) demonstrated apnea in association with RSV infection. Predisposing factors significantly correlated with apnea included premature birth and young chronologic age at the time of virus infection. The clinical implications of this association are discussed.

References (23)

  • HolzelA et al.

    The isolation of respiratory syncytial virus from children with acute respiratory disease

    Lancet

    (1963)
  • OgraPL et al.

    Secretory component and sudden infant death syndrome

    Lancet

    (1975)
  • ChanockRM et al.

    Respiratory syncytial virus. I. Virus recovery and other observations during 1960 outbreak of bronchiolotis, pneumonia, and minor respiratory diseases in children

    JAMA

    (1961)
  • KimHW et al.

    Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract syndromes andtemporal distribution of infection

    Am J Epidemiol

    (1973)
  • BrandtCD et al.

    Epidemiology of respiratory syncytial virus infection in Washington, D.C. III. Composite analysis of eleven consecutive yearly epidemics

    Am J Epidemiol

    (1973)
  • GardnerPS

    Virus infections and respiratory disease of children

    Arch Dis Child

    (1968)
  • DennyF

    The replete pediatrician and the etiology of lower respiratory tract infections

    Pediatr Res

    (1969)
  • BeemM et al.

    Association of the chimpanzee coryza agent with acute respiratory disease in children

    N Engl J Med

    (1960)
  • ReillyCM et al.

    Studies of acute respiratory illness caused by respiratory syncytial virus. 3. Clinical and laboratory findings

    N Engl J Med

    (1961)
  • LennetteEH et al.

    Diagnostic procedures for viral and rickettsial infections

    (1969)
  • NeliganGA et al.

    RSV infection of the newborn

    Br Med J

    (1970)
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    1

    Supported in part by Contract N01-AI-22501 and Grant HD-06819 from the National Institutes of Health.

    Presented in part to the Society for Pediatric Research, Denver, Colo., Spring, 1975.

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