In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin: 3. Effects on spermatogenesis and reproductive capability☆
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2020, Reproductive ToxicologyCitation Excerpt :2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced male reproductive toxicity has been studied extensively in the rat, and fetal rat exposure reduces epididymal sperm concentration. Compared to exposure beginning after parturition, rat exposure beginning on GD 15 has more robust effects on epididymal sperm endpoints [2–6], indicating the rat fetal period is the most sensitive exposure window. However, the reduced cauda epididymal sperm response not been observed across all studies, which introduces uncertainty as to whether or not this response is a sensitive target organ effect of TCDD [7,8].
Developmental and reproductive toxicity of TCDD, lead and mercury
2019, Encyclopedia of Environmental Health
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Supported by NIH Grant ES01332. This article is Contribution 248, Environmental Toxicology Center, University of Wisconsin, Madison, WI 53706. Portions of this research were presented at the annual meeting of the Society of Toxicology (Toxicologist 10, 313 1990) and in Banbury Report 35, Biological Basis for Risk Assessment of Dioxins and Related Compounds (M. A. Gallo, R. J. Scheuplein, and C. A. van der Heijden, Eds.), pp. 69–78, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 1991.
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