Gray platelet syndrome: A variety of qualitative platelet disorder

doi:10.1016/0002-9343(71)90311-1

The American Journal of Medicine

Volume 51, Issue 6, December 1971, Pages 818-828

https://doi.org/10.1016/0002-9343(71)90311-1 Get rights and content

Abstract

An eleven year old child with a bleeding tendency since infancy is described. The hemorrhagic disorder was characterized by thrombocytopenia and morphologic abnormalities of platelets and megakaryocytes, consisting of lack or paucity of granules and a peculiar gray color. Thrombocytopenia was corrected temporarily by corticosteroid therapy and permanently by splenectomy. However, morphologic abnormalities, poor clot retraction and prolonged bleeding time persisted. The platelets aggregated normally with adenosine diphosphate (ADP), collagen and epinephrine. Thrombasthenin, fibrinogen and ADP content were normal. Adenosine triphosphate (ATP) content was 50 per cent of normal. Platelet phosphatides were significantly decreased, and phosphatidyl serine could not be identified chromatographically.

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^☆: This study was supported by Public Health Service Grant No. HEO8743.

¹: From the University of Louisville School of Medicine, Department of Medicine, Division of Hematology, Louisville, Kentucky 40202.

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Case reportGray platelet syndrome: A variety of qualitative platelet disorder☆

Abstract

Blood

Blood

The Lancet

Blood

J Biol Chem

J Biol Chem

Blood

Amer J Med

Amer J Med

Blood

Blood

Lancet

Hereditäre hämorrhagische Thrombasthenie

Jhrb Kinderheilkunde

Thrombasthenia. Platelets: their role in hemostasis and thrombosis

Thromb Diath Haemorrh

A new approach to the thrombocytopathies. Thrombocytopathy A

Thromb Diath Haemorrh

A new abnormality of platelet function

Thromb Diath Haemorrh

The blood platelets

Glanzmann's thrombopathy: an autosomal recessive trait in one family

Amer J Med Sci

Thrombopathia

Acta Haemat (Basel)

A familial platelet disease. Hereditary thrombasthenic-thrombopathic thrombocytopenia

Scand J Clin Lab Invest

Thrombopénie avec thrombasthénie

Sang

A thrombasthenic syndrome associated with hyperheparinemia

Ann Intern Med

Sur une nouvelle variété de dystrophie thrombocytaire hémorragipare congénitale

Sem Hop Paris

La thrombocytopathie granulopénique

Rev d'hémat

Diathèse hémorragique a plaquettes rondes et isolées: succès passager des oestrogènes de synthèse

Sang

Thrombopathie familiale

Schweiz Med Wschr

Hereditary thrombopathic thrombocytopenia: sex linked inheritance pattern

Amer J Med Sci

Hereditary thrombopathic thrombocytopenia

Amer J Med Sci

Spontaneous bruising associated with a defect in the interaction of platelets with connective tissue

The Lancet

A propos de trois nouveaux cas de “diacyclothrombopathie.” L'épreuve de l'étalement des plaquettes au contraste de phase

Sang

Un nouveau cas de diacyclothrombopathie: heureuse influence de la cortisone

Sang

Platelet dysfunction. Differentiation of a newly recognized primary type from that produced by aspirin

New Eng J Med

Familial thrombocytopenic thrombocytopathy

Brit J Haemat

The qualitative platelet diseases

Blood Coagulation, Hemorrhage and Thrombosis

Case report
Gray platelet syndrome: A variety of qualitative platelet disorder☆