Abstract
Sixty-nine early morning urine samples obtained from three groups of young adult males (autistic, mentally handicapped, and a group of men of normal intelligence) were analyzed using the methods described by Trygstad et al. (1980). No consistent patterns of urinary chromatographic profiles were identified. A number of possible contributing factors are discussed in relation to this failure to replicate the results of previous studies.
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References
American Psychiatric Association. (1980).Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: Author.
August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children.British Journal of Psychiatry, 138, 416–422.
Bartak, L., Rutter, M., & Cox, A. (1975). A comparative study of infantile autism and specific developmental receptive language disorder.British Journal of Psychiatry, 126, 127–145.
Blomquist, H.K., Bohman, M., Edvinsson, S. O., Gillberg, C., Gustavon, K. H., Homgren, G., & Wahlstrom, J. (1985). Frequency of the fragile X syndrome in infantile autism: a Swedish multicenter study.Clinical Genetics, 27, 113–117.
Brown, W. T., Jenkins, E. C., Cohen, I. L., Fisch, G. S., Wold-Schein, E. G., Gross, A., Waterhouse, L., Fein, D., Mason-Brothers, A., Ritvo, E., Ruttenberg, B. A., Bentley, W., Castells, S. (1986). Fragile X and autism: A multicenter survey.American Journal of Medical Genetics, 23, 241–252.
Bundey, S., Webb, T. P., Thake, A., & Todd, J. (1985). A community study of severe mental retardation in the West Midlands and the importance of the fragile X chromosome in its aetiology.Journal of Medical Genetics, 22, 258–266.
Chess, S. (1979). Follow-up report on autism in congenital rubella.Journal of Autism and Developmental Disorders, 7, 69–81.
Chess, S., Korn, S. J., & Fernandez, B. (1971).Psychiatric disorders of children with congenital rubella. New York: Brunner/Mazel.
Coleman, M. (Ed.). (1976).The autistic syndrome. Amsterdam: North Holland.
Coleman, M., & Gillberg, C. (1987).The biology of the autistic syndrome (2nd ed.). New York: Praeger.
Deutsch, S. I., Milstoc, M., Platovsky, G., Wolksy, B. B., Perry, R., & Green, W. I. (1987). Cholinesterase activities in blood in infantile autism.Biological Psychiatry, 22, 234–236.
Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs.Journal of Child Psychology and Psychiatry, 18, 297–231.
Folstein, S., & Rutter, M. (1987). Autism Family aggregation and genetic implications. In E. Schopler & G. B. Mesibov (Eds.),Neurobiological issues in autism (pp. 83–105. New York: Plenum Press.
Foss, I., Schulman, A., Trygstad, O., & Wetterberg, L. (1983). Chromatographic analysis of urine and dialysate from schizophrenic patients undergoing haemodialysis.Artificial Organs, 7, 349–352.
Foss, I., & Trygstad, O. E. (1975). Lipodystrophy produced in mice and rabbits by a fraction prepared from the urine from patients with congenital generalised lipodystrophy.Acta Endocrinologica, 80, 398–416.
Gillberg, C., Trygstad, O., & Foss, I. (1982).Childhood psychosis and urinary excretion of peptides and protein-associated peptide complexes.Journal of Autism and Developmental Disorders, 12, 3, 229–241.
Gillberg, C., & Wahlstrom, J. (1985). Chromosome abnormalities in infantile autism and other childhood psychoses: A population study of 66 cases.Developmental Medicine and Child Neurology, 27, 293–304.
Gilroy, J., & Rowell, F. (1987).Urinary peptide metabolites in autism. Presentation at NAS conference, Canterbury, Kent.
Jaeken, J., & Van Den Berghe, G. (1984). An infantile autistic syndrome characterised by the presence of succinylpusines in body fluids.Lancet, 2, 1058–1061.
Kuperman, S., Beeghly, J. H. L., Burns, T. L., & Tsai, L. T. (1985). Serotonin relationships of autistic probands and their first degree relatives.Journal of American Academy of Child Psychology, 24, 186–190.
Lejeune, J. (1982). Is the Fragile-X syndrome amenable to treatment.Lancet, 1, 273–274.
Pare, C. M. B., Sandler, M., & Stacey, R. S. (1960). 5-Hydroxyindoles in mental deficiency.Journal of Neurology, Neurosurgery and Psychiatry, 23, 341–346.
Parrington, M. W., Tu, J. B., & Wong, C. Y. (1973). Blood serotonin levels in severe mental retardation.Developmental Medicine and Child Neurology, 15, 616–627.
Reichelt, K. L., Foss, I., Trygstad, O. E., Edminson, P. D., & Boler, J. B. (1978). Humoral control of appetite: II. Purification and characterization of an anorexogenic peptide from human urine.Nueroscience, 3, 1207–1211.
Rutter, M. (in press). Biological basis of autism: Implications for intervention. In F. J. Menolascino & J. A. Stark (Eds.),Curative aspects of mental retardation: Biomedical and behavioral advances (Vol. 2). Baltimore: Brookes.
Rutter, M., & Schopler, E. (1978). Developmental issues and prognosis. In M. Rutter & E. Schopler (Eds.),Autism: A reappraisal of concepts and treatment (pp. 1–25). New York: Plenum Press.
Sankar, D. V. S. (1979). Plasma levels of folates, Riboflavin, vitamin B, and ascorbate in severely disturbed children.Journal of Autism and Developmental Disorders, 9, 73–82.
Stubbs, E. G. (1978). Autistic symptoms in a child with congenital cytomegalovirus.Journal of Autism and Childhood Schizophrenia, 8, 37–43.
Taft, L. T., & Cohen, J. J. (1971). Hypsarrhythmia and infantile autism: A clinical report.Journal of Autism and Childhood Schizophrenia, 1, 327–336.
Trygstad, O. E., Reichelt, K. L., Foss, I., Edminson, P. D., Saelid, G., Bremer, J., Hole, K., Orebeck, H., Johansen, J. H., Boler, J. B., Titlestad, K., & Opstad, P. K. (1980). Patterns of peptides and protein-associated peptide complexes in psychiatric disorders.British Journal of Psychiatry, 136, 59–72.
World Health Organization. (1987).ICD-10: 1986 Draft of Chapter V, Categories F00-F99 Mental, behavioural and developmental disorders. Geneva: Author.
Young, J. G., Kavanagh, M. E., Anderson, G. M., Shaywitz, B. A., Cohen, D. J. (1982). Clinical neurochemistry of autism and associated disorders.Journal of Autism and Developmental Disorders, 12, 147–165.
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Our grateful thanks to the staff and residents of the residential units for young autistic adults, staff and clients at Brixton Adult Training Centre, Leybourne Grange Hospital and all the volunteers who took part in this study. Thanks also to Anne Ross for her secretarial assistance. This work partly funded by the MacArthur Research Foundation.
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Le Couteur, A., Trygstad, O., Evered, C. et al. Infantile autism and urinary excretion of peptides and protein-associated peptide complexes. J Autism Dev Disord 18, 181–190 (1988). https://doi.org/10.1007/BF02211945
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DOI: https://doi.org/10.1007/BF02211945