eLetters

492 e-Letters

published between 2005 and 2008

  • Re: how long will supplements be effective.
    Richard G Fiddian-Green

    Dear Editor,

    L carnitine is needed for the transport of long-chain fatty acids across the mitochondrial membrane for oxidation into acetyl coenzyme A and entry into the Krebs cycle. Long-chain fatty acids nay also increase temperature, and hence metabolic rate, oxygen consumption [Q10 effect] and net ATP yield by uncoupling oxidative phosphorylation. If excessive the uncoupling might have the reverse effect....

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  • Childhood growth influences cognition in the Thousand Families study, but not income at age 50.
    Mark S Pearce

    Dear Editor,

    Barker et al. recently reported a relationship between short length at age 1 year and lower incomes in adulthood [1]. Citing results from an early report from the Newcastle Thousand Families Study showing a relationship between height at age 3 years and intelligence at age 11 [2]. Barker et al. interpreted this as evidence that slow infant growth may lead to a lifelong impairment of cognitive functio...

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  • Irreversible shock, gastric intramucosal pH and energy charge.
    Richard G Fiddian-Green

    Dear Editor,

    Septic shock is characterised by a hyperdynamic, vasodilated circulation associated with cytolin release and its inhibitory effect upon oxygen uptake and utilisation. Most deaths are late and occur after patients have developed multiple organ dysfunctions. In these cases cardiac arrest is preceded by a declining cardiac output the invariable cause of death. Haemorrhagic shock differs only in that i...

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  • Bruising in pre-school children with special needs
    Fiona Finlay

    Dear Editor,

    The authors are to be congratulated for the systematic review 'Are there patterns of bruising in childhood which are diagnostic or suggestive of abuse?' It is an extremely valuable piece of work, providing data for paediatricians working in the field of child protection.

    Results show that non-abusive bruises are generally small, sustained over bony prominences and found on the front of the...

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  • Automatic external defibrillation in a 6 year old
    Robert M Bingham

    Dear Editor,

    We were interested in the article by Konig, Benger and Goldsworthy [1] describing the use of an Automated External Defibrillator (AED) in a 6- year-old child and would like to congratulate them and the paramedic team on saving this girl’s life.

    As the authors point out in their discussion, data on the use of AEDs in children is scant and any publication in this area is encouraged. In the ab...

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  • If community paediatrician did not exist, it would be necessary to invent them
    Cliona M Ni Bhrolchain

    Dear Editor,

    Since 1991 there has been talk of abolishing community paediatrics as a specialty [1]. At that time, a group of related specialties was proposed: a specialty of child development and rehabilitation (neurodisability); child protection would be subsumed into general paediatrics and there would be child public health doctors. Since then there has been a view amongst some paediatricians that community...

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  • HOW LONG IS CARNITINE EFFECTIVE IN CYCLIC VOMITING SYNDROME?
    Mukadder A. Selimoglu

    Dear Editor,

    We read the article of McLoughlin et al. [1], reporting a 7 year old boy with cyclic vomiting syndrome (CVS), whose episodes were controlled by L- carnitine, with great interest. Here we present a 10 year-old girl with CVS, whose episodes were also controlled by L-carnitine, but restarted after an eight-month period.

    The first episode of our patient was at 1 year of age, which was characteri...

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  • The larger the better?
    Yu-Kang Tu

    Dear Editor,

    It is interesting to note that now birth size is shown to be related to income in later life! However, I wonder whether a correlation of 0.04 or 0.1 can be considered substantial. Although the P values are impressive (<_0 it="it" is="is" due="due" to="to" the="the" relative="relative" large="large" sample="sample" size="size" in="in" their="their" study="" p="p"> Another interesting po...

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  • Effectiveness of tonsillectomy depends on stringency of indications
    Jack L Paradise
    Dear Editor,

    The meta-analysis of adenotonsillectomy trial results reported by van Staaij and colleagues[1], from which they concluded that the operation confers “an additional, but small, reduction of sore throat episodes . . . compared to watchful waiting,” falls short on numerous counts and misleads the unwary reader.

    Their analysis of the trials conducted between the 1920s and 1960s not only overlooks prev...

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  • Early enteral iron supplementation in very low birth weight infants
    Filiz Tiker

    Dear Editor,

    We read with interest the recent article by Aggarwal et al evaluating the haematological effect of iron supplementation in breast fed term low birth weight (LBW) infants. [1]

    Low birth weight infants are more susceptible to iron deficiency owing to their proportionately smaller iron store at birth and their relative higher growth rate in the first months of life. Erythropoiesis at all ages...

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