163 e-Letters

published between 2011 and 2014

  • Re - Leading article: Is it farewell to codeine? By Brian J Anderson
    Andrew Will

    I read Dr Anderson's article with interest because the removal of codeine from the pharmacopeia for children under 12 years of age has caused difficulty in my clinical practice.

    I am a paediatric haematologist and in my unit in Manchester there are over 420 children registered with bleeding disorders and another 100 or so on long term warfarin. The use of non-steroidal analgesics (NSAID) is contra-indicated in...

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  • Is the effect of parental separation underestimated?
    Michael A. Colvin

    Morinis et al conclude that there remains a significant adverse effect on verbal abilities in children born to teenage mothers at age five years of age after adjustment for sociodemographic circumstances and perinatal risk. However there appears to be a flaw in the methodology of the study which undermines its findings. In the characteristics of the study population by age group (table 1), the response "Father at home- No...

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  • Re: re; Undescended testis
    Caroline CP Ong

    We welcome the interest in our study reviewing the epidemiology and referral patterns for boys with cryptorchidism.

    We are in agreement with Dr Hadziselimovic that the retractile testis is often misdiagnosed as undescended testis. However, we do not share his experience that over half of patients 'sent' for treatment meet the criteria for retractile testis. In our study, only 5% of boys had retractile testis. In...

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  • Management of Kawasaki disease Eleftheriou et al
    Susan M Hall

    The authors recommend that children on long term aspirin therapy for complications of Kawasaki Disease should be immunised with varicella zoster vaccine because of the risk of Reye's syndrome (RS) if they acquire chicken pox. It is equally important that they receive influenza vaccine annually because influenza is also associated with the development of RS in children taking aspirin. In fact one of the groups listed as el...

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  • re; Undescended testis
    Faruk Hadziselimovic

    I read with interest the paper by Drs Nah and colleagues on; Undescended testis;513 patients' characteristics, age at orchidopexy and patterns of referral (1). The objective of this study was to describe current practice at the time of orchidopexy . The results obtained should help to identify the corrections necessary to optimize the treatment Several principal questions should be raised: 1. The greatest challenge in a d...

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  • Re:Writing a scientific paper: devil is in the details
    Mandy Wan

    We thank Dr Hemila for sharing his work on Vitamin C with us. Dr Hemila draws our attention to his analysis of the work by Karlowski et al., which we read with interest. We are certainly in agreement with Dr Hemila that "technically the Karlowski study is not among the best" with regards to blinding.

    In our paper, the referenced Karlowski article was an example of how inadequate blinding can lead to questions...

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  • Poisson distribution applied to suicide data
    Thomas J P Verberne

    More than half a century ago, M. J. Moroney pointed out that ". . . the Poisson distribution may only be applied in cases where the expectation, z, is constant from trial to trial. Thus, it does not apply to the number of suicides per year in a given community, because the temptation to commit suicide varies with the stress of the times, . . ." (Facts from figures, 1956, pp 100-101.

    Conflict of Interest:

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  • Writing a scientific paper: devil is in the details
    Harri Hemila

    In their short review, Wan et al. refer to the Karlowski et al. (1975) study (1) as an example of problems caused by shortcomings in blinding. Karlowski et al. found that vitamin C significantly shortened the duration of colds; however, they proposed that the benefit of vitamin C was causd by the placebo effect (1).

    However, the placebo-effect explanation of Karlowski et al. was shown to be erroneous 2 decades a...

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  • Bronchial balloon occlusion in children with complex pulmonary air leaks
    Claire G. Hathorn

    We would like to thank Drs Jakob and Hentschel for their response to our recent paper concerning the use of balloon occlusion catheters. Their experience of single lung ventilation of preterm infants is very useful. Our paper covered the use of balloon occlusion across a wider age range: from preterm infants up to 6 years age. The mainstem bronchi are so short in preterm infants that a balloon has only a small 'foothold'...

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  • What gets lost in translation?
    Edwin Spaans

    With pleasure we read the article by Allegaert et al(1) on the use of paracetamol for ductus arteriosus closure with high doses of paracetamol (15mg/kg q6h) and the response by Mazer-Amishahi(2). The authors propose to initiate a prospective randomized controlled trial. Before embarking on such a 'Proof of Concept' (POC) study, translational considerations may provide usefull insights.

    The considered mode of acti...

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