<!doctype html> <!--[if lt IE 7]> <html class="no-js lt-ie10 lt-ie9 lt-ie8 lt-ie7" lang="en"> <![endif]--> <!--[if IE 7]> <html class="no-js lt-ie10 lt-ie9 lt-ie8" lang="en"> <![endif]--> <!--[if IE 8]> <html class="no-js lt-ie10 lt-ie9" lang="en"> <![endif]--> <!--[if IE 9]> <html class="no-js lt-ie10" lang="en"> <![endif]--> <!--[if gt IE 9]><!--> <html class="no-js" lang="en"> <!--<![endif]--> <head> <meta name="viewport" content="width=device-width,initial-scale=1"> <link rel="shortcut icon" href="http://bmj.com/wp-content/themes/jnp-base/favicon.ico" /> <script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','');</script> <script> var oas_tag = oas_tag || {}; oas_tag.url = 'oas.services.bmj.com'; oas_tag.sizes = function () { oas_tag.definePos('Top', [728,90]); oas_tag.definePos('Middle1', [300,250]); oas_tag.definePos('Bottom', [728,90]); }; oas_tag.site_page = window.location.hostname + window.location.pathname; oas_tag.query = ''; oas_tag.allowSizeOverride = true; oas_tag.analytics = true; oas_tag.taxonomy = ''; (function() { oas_tag.version ='1'; oas_tag.loadAd = oas_tag.loadAd || function(){}; var oas = document.createElement('script'), protocol = 'https:' == document.location.protocol?'https://':'http://', node = document.getElementsByTagName('script')[0]; oas.type = 'text/javascript'; oas.async = true; oas.src = protocol + oas_tag.url + '/om/' + oas_tag.version + '.js'; node.parentNode.insertBefore(oas, node); })(); </script> <link rel='dns-prefetch' href='//bmj.com' /> <link rel='dns-prefetch' href='//s.w.org' /> <script type="text/javascript"> window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/2.2.1\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/2.2.1\/svg\/","svgExt":".svg","source":{"concatemoji":"http:\/\/bmj.com\/wp-includes\/js\/wp-emoji-release.min.js?ver=4.7.1"}}; !function(a,b,c){function d(a){var b,c,d,e,f=String.fromCharCode;if(!k||!k.fillText)return!1;switch(k.clearRect(0,0,j.width,j.height),k.textBaseline="top",k.font="600 32px Arial",a){case"flag":return k.fillText(f(55356,56826,55356,56819),0,0),!(j.toDataURL().length<3e3)&&(k.clearRect(0,0,j.width,j.height),k.fillText(f(55356,57331,65039,8205,55356,57096),0,0),b=j.toDataURL(),k.clearRect(0,0,j.width,j.height),k.fillText(f(55356,57331,55356,57096),0,0),c=j.toDataURL(),b!==c);case"emoji4":return k.fillText(f(55357,56425,55356,57341,8205,55357,56507),0,0),d=j.toDataURL(),k.clearRect(0,0,j.width,j.height),k.fillText(f(55357,56425,55356,57341,55357,56507),0,0),e=j.toDataURL(),d!==e}return!1}function e(a){var c=b.createElement("script");c.src=a,c.defer=c.type="text/javascript",b.getElementsByTagName("head")[0].appendChild(c)}var f,g,h,i,j=b.createElement("canvas"),k=j.getContext&&j.getContext("2d");for(i=Array("flag","emoji4"),c.supports={everything:!0,everythingExceptFlag:!0},h=0;h<i.length;h++)c.supports[i[h]]=d(i[h]),c.supports.everything=c.supports.everything&&c.supports[i[h]],"flag"!==i[h]&&(c.supports.everythingExceptFlag=c.supports.everythingExceptFlag&&c.supports[i[h]]);c.supports.everythingExceptFlag=c.supports.everythingExceptFlag&&!c.supports.flag,c.DOMReady=!1,c.readyCallback=function(){c.DOMReady=!0},c.supports.everything||(g=function(){c.readyCallback()},b.addEventListener?(b.addEventListener("DOMContentLoaded",g,!1),a.addEventListener("load",g,!1)):(a.attachEvent("onload",g),b.attachEvent("onreadystatechange",function(){"complete"===b.readyState&&c.readyCallback()})),f=c.source||{},f.concatemoji?e(f.concatemoji):f.wpemoji&&f.twemoji&&(e(f.twemoji),e(f.wpemoji)))}(window,document,window._wpemojiSettings); </script> <style type="text/css"> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 .07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='jnp-base-css' href='http://bmj.com/wp-content/themes/jnp-base/css/style.css?ver=4.7.1' type='text/css' media='all' /> <style id='jnp-base-inline-css' type='text/css'> .primary-color { background-color: !important; } div.widget-circles a:hover span { background-color: !important; } </style> <!--[if lt IE 9]> <script type='text/javascript' src='http://bmj.com/wp-content/themes/jnp-base/js/lib/html5shiv-3.7.3.min.js?ver=4.7.1'></script> <![endif]--> <script type='text/javascript' src='http://bmj.com/wp-includes/js/jquery/jquery.js?ver=1.12.4'></script> <script type='text/javascript' src='http://bmj.com/wp-includes/js/jquery/jquery-migrate.min.js?ver=1.4.1'></script> <script type='text/javascript'> /* <![CDATA[ */ var ajax_object = {"ajax_url":"http:\/\/bmj.com\/wp-admin\/admin-ajax.php"}; /* ]]> */ </script> <script type='text/javascript' src='http://bmj.com/wp-content/themes/jnp-base/js/jnp-base.js?ver=4.7.1'></script> <link rel='https://api.w.org/' href='http://bmj.com/wp-json/' /> <link rel="EditURI" type="application/rsd+xml" title="RSD" href="http://bmj.com/xmlrpc.php?rsd" /> <link rel="wlwmanifest" type="application/wlwmanifest+xml" href="http://bmj.com/wp-includes/wlwmanifest.xml" /> <meta name="generator" content="WordPress 4.7.1" /> <meta name='robots' content='noindex,follow' /> <style type="text/css"> .mu_register { width: 90%; margin:0 auto; } .mu_register form { margin-top: 2em; } .mu_register .error { font-weight:700; padding:10px; color:#333333; background:#FFEBE8; border:1px solid #CC0000; } .mu_register input[type="submit"], .mu_register #blog_title, .mu_register #user_email, .mu_register #blogname, .mu_register #user_name { width:100%; font-size: 24px; margin:5px 0; } .mu_register #site-language { display: block; } .mu_register .prefix_address, .mu_register .suffix_address {font-size: 18px;display:inline; } .mu_register label { font-weight:700; font-size:15px; display:block; margin:10px 0; } .mu_register label.checkbox { display:inline; } .mu_register .mu_alert { font-weight:700; padding:10px; color:#333333; background:#ffffe0; border:1px solid #e6db55; } </style> </head> <body class="home blog"> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="container"> <header> <section class="cookie closed"> <div id="close-cookie"><img src="//resources.bmj.com/repository/journals-network-project/images/wordpress/icon-close.png" srcset="data:image/svg+xml;base64,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"></div> <p>This site uses cookies. <span id="cookie-more">More info <img src="//resources.bmj.com/repository/journals-network-project/images/wordpress/icon-arrow-down.png" srcset="data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCA0OCA0OCI+PHBvbHlnb24gcG9pbnRzPSI5IDMzLjQgNy42IDMyLjEgMjQuNCAxNC42IDQwLjQgMzIuMSAzOC45IDMzLjQgMjQuNCAxNy41ICIgZmlsbD0iI2ZmZiIvPjwvc3ZnPgo="></span><span class="info">By continuing to browse the site you are agreeing to our use of cookies. <a href="http://company.bmj.com/privacy-policy/#cookies">Find out more here.</a></span></p> </section> <section class="advert"> <div id="oas_Top"> <script type="text/javascript">oas_tag.loadAd("Top");</script> </div> </section> <section class="nav-journals"> <a href="//journals.bmj.com/"><img src="//resources.bmj.com/repository/journals-network-project/images/wordpress/logo-bmj-journals.png" srcset="//resources.bmj.com/repository/journals-network-project/images/wordpress/logo-bmj-journals.svg"></a> <div class="menu-journals-menu-container"><ul id="menu-journals-menu" class="desktop menu"><li id="menu-item-69" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-69"><a href="http://bmj.com/?page_id=43">Subscribe</a></li> <li class="menu-item search-form"><form role="search" method="post" class="search-form" action="/search" id="highwire-search-quicksearch-form-1" accept-charset="UTF-8" ><input type="textbox" class="search-field" placeholder="search" value="" name="keywords" title="Search for:" ><input type="submit" class="search-submit" name="op" value="Search" ><input type="hidden" name="form_id" value="highwire_search_quicksearch_form_1" ><p class="advanced"><span><a href="/search"><span>Advanced</span> <span>search</span></a></span></p></form> </li><li class="menu-item search closed"><a href="#">Search <div class="svg-wrapper"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48"><style>fill: #333; stroke: #333;</style><path d="M17.9 36.2C9.1 36.2 2 29.1 2 20.3S9.1 4.5 17.9 4.5s15.9 7.1 15.9 15.8S26.6 36.2 17.9 36.2zM17.9 6.5C10.2 6.5 4 12.7 4 20.3c0 7.6 6.2 13.8 13.9 13.8 7.7 0 13.9-6.2 13.9-13.8C31.8 12.7 25.5 6.5 17.9 6.5z"></path><polygon points="29.3 30.1 31.9 29.6 46 40.4 44.8 41.9 "></polygon><polygon points="29.3 30.1 29.5 32.7 43.6 43.5 44.8 41.9 "></polygon></svg></div></a></li></ul></div></section> <section class="nav-journal primary-color"> <div> <a href="/"><img id="journal-logo" src="//resources.bmj.com/repository/journals-network-project/images/journal-logos/logo-.png" srcset="//resources.bmj.com/repository/journals-network-project/images/journal-logos/logo-.svg"></a> <section class="nav-desktop"> <div class="journal-menu header-menu"><ul id="menu-journal-menu" class="menu"><li id="menu-item-46" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-46"><a href="//.bmj.com/content/early/recent">Online First</a></li> <li id="menu-item-47" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-47"><a href="//.bmj.com/content/current">Current Issue</a></li> <li id="menu-item-48" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-48"><a href="//.bmj.com/content/by/year">Archive</a></li> <li id="menu-item-49" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-49"><a href="http://bmj.com/?page_id=38">Authors</a></li> <li id="menu-item-50" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-50"><a href="http://bmj.com/?page_id=37">About</a></li> </ul></div></section> <section class="nav-mobile"> <ul> <li class="search closed"><img srcset="data:image/svg+xml;base64,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" src="//resources.bmj.com/repository/journals-network-project/images/wordpress/icon-search.png"></li><!-- --><li class="burger closed"><img srcset="data:image/svg+xml;base64,PHN2ZyB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciIHZpZXdCb3g9IjAgMCA0OCA0OCI+PHN0eWxlPi5he2ZpbGw6I2ZmZjt9PC9zdHlsZT48cmVjdCB4PSI4IiB5PSIxNC41IiB3aWR0aD0iMzIiIGhlaWdodD0iMyIgY2xhc3M9ImEiLz48cmVjdCB4PSI4IiB5PSIyMi41IiB3aWR0aD0iMzIiIGhlaWdodD0iMyIgY2xhc3M9ImEiLz48cmVjdCB4PSI4IiB5PSIzMC41IiB3aWR0aD0iMzIiIGhlaWdodD0iMyIgY2xhc3M9ImEiLz48L3N2Zz4K" src="//resources.bmj.com/repository/journals-network-project/images/wordpress/icon-hamburger-menu.png"></li> </ul> </section> </div> </section> <section class="nav-crumb"> <div> <div> <div class="crumbs"> </div> <div class="email"><a href="/alerts"><div class="svg-wrapper"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 33 22"> <style>.a{fill:none;}</style> <rect x="0.5" y="0.5" width="32" height="21" class="a"></rect> <polyline points="0.6 0.7 16.6 13.4 32.4 0.9 " class="a"></polyline> <line x1="0.8" y1="21.3" x2="11.6" y2="9.8" class="a"></line> <line x1="32.4" y1="21.5" x2="21.5" y2="9.7" style="fill:none;stroke-linejoin:round;"></line> </svg></div>Email alerts</a></div> </div> </div> </section> </header> <div id="signup-content" class="widecolumn"> <div class="mu_register wp-signup-container"> Registration has been disabled.</div> </div> <footer> <nav class="primary-color"> <div class="wrapper"> <div><div class="footer-menu-a footer-menu"><h3>Content</h3><ul id="menu-content" class="menu"><li id="menu-item-51" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-51"><a href="//.bmj.com/content/early/recent">Online First</a></li> <li id="menu-item-52" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-52"><a href="//.bmj.com/content/current">Current Issue</a></li> <li id="menu-item-53" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-53"><a href="//.bmj.com/content/by/year">Archive</a></li> <li id="menu-item-54" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-54"><a href="http://bmj.com/?page_id=41">Topic collections</a></li> <li id="menu-item-55" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-55"><a href="//.bmj.com/alerts/toc/edit?destination=">Sign up for email alerts</a></li> </ul></div></div><div><div class="footer-menu-b footer-menu"><h3>Journal</h3><ul id="menu-journal" class="menu"><li id="menu-item-56" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-56"><a href="http://bmj.com/?page_id=37">About</a></li> <li id="menu-item-57" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-57"><a href="http://bmj.com/?page_id=44">Editorial Board</a></li> <li id="menu-item-59" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-59"><a href="http://bmj.com/?page_id=45">Thank you to the reviewers</a></li> <li id="menu-item-61" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-61"><a href="http://bmj.com/?page_id=40">Most read</a></li> <li id="menu-item-64" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-64"><a href="http://bmj.com/?page_id=43">Your subscription options</a></li> </ul></div></div> </div><div class="wrapper"> <div><div class="footer-menu-c footer-menu"><h3>Authors</h3><ul id="menu-authors" class="menu"><li id="menu-item-58" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-58"><a href="http://bmj.com/?page_id=38">Instructions for authors</a></li> <li id="menu-item-60" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-60"><a href="http://mc.manuscriptcentral.com/">Submit a paper</a></li> <li id="menu-item-62" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-62"><a href="http://authors.bmj.com/open-access/">Open Access at BMJ</a></li> </ul></div></div><div><div class="footer-menu-d footer-menu"><h3>Help</h3><ul id="menu-help" class="menu"><li id="menu-item-63" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-63"><a href="http://bmj.com/?page_id=39">Contact us</a></li> <li id="menu-item-65" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-65"><a href="http://journals.bmj.com/cgi/reprintform">Reprints</a></li> <li id="menu-item-66" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-66"><a href="http://www.bmj.com/company/products-services/rights-and-licensing/permissions">Permissions</a></li> <li id="menu-item-67" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-67"><a href="http://www.bmj.com/company/contact-us/advertising-sponsorship/">Advertising</a></li> <li id="menu-item-68" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-68"><a href="http://myaccount.bmj.com/myaccount/customerservice/salesforce-form.html">Feedback form</a></li> </ul></div></div> </div> </nav> <section class="platform"> <div class="logo"> <a href="http://www.bmj.com/company"><img src="//resources.bmj.com/repository/journals-network-project/images/wordpress/logo-bmj-footer.png" srcset="//resources.bmj.com/repository/journals-network-project/images/wordpress/logo-bmj-footer.svg"></a> </div><div class="menu"> <ul> <li><a href="http://www.bmj.com/company/legal-information/">Website Terms &amp; Conditions</a></li> <li><a href="http://www.bmj.com/company/your-privacy/">Privacy &amp; Cookies</a></li> <li><a href="http://www.bmj.com/company/contact-us/">Contact BMJ</a></li> </ul> </div><div class="content"> <p></p> <p>Copyright &copy; 2017 . All rights reserved.</p> <p>京ICP备15042040号-3</p> </div> </section> <script type='text/javascript' src='http://bmj.com/wp-content/themes/jnp-base/js/feedbackify.js?ver=4.7.1'></script> <script type='text/javascript' src='http://bmj.com/wp-includes/js/wp-embed.min.js?ver=4.7.1'></script> </footer> </div> </body> </html>
rss

Online First


Online First articles have been peer reviewed, accepted for publication, published online and indexed by PubMed; they have not yet been assigned to a journal issue. When an article is published in an issue it will be removed from this page.

Online First articles are copy-edited, typeset and approved by the author before publication and we aim to post each article within 3 weeks of acceptance.

Articles appear on this page in reverse chronological order; you may also view by section by clicking on the link at the top of the column to the right.

More about Online First, including how to cite >>

View multiple abstracts by picking relevant boxes and click Get all checked abstracts

Archimedes

Case report

Editorial

Global child health

Images in paediatrics

Leading article

Original article

PostScript

Quality reports

Review

Short report

Short research report

View multiple abstracts by picking relevant boxes and click Get all checked abstracts

Free sample

This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of ADC.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.