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Outcomes of neonatal jaundice in Taiwan
  1. Pei-Chen Tsao1,2,3,4,
  2. Hsin-Ling Yeh5,
  3. Yen-Chen Chang5,
  4. Po-Huang Chiang5,
  5. Yu-Shih Shiau6,
  6. Szu-Hui Chiang6,
  7. Wen-Jue Soong1,2,4,
  8. Mei-Jy Jeng1,2,4,
  9. Kwang-Jen Hsiao6
  1. 1Division of General Pediatrics, Pediatrics Department, Taipei Veterans General Hospital, Taipei, Taiwan
  2. 2Department of Pediatrics, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  3. 3Institute of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  4. 4Institute of Emergency and Critical Care Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan
  5. 5The Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
  6. 6Preventive Medicine Foundation, Taipei, Taiwan
  1. Correspondence to Professor Kwang-Jen Hsiao, Preventive Medicine Foundation, Taipei 10699, Taiwan; hsiao{at}pmf.tw

Abstract

Objective To investigate the burden of clinically significant neonatal jaundice (SNJ) in Taiwan, 20002010.

Study design The nationwide, population-based health insurance database in Taiwan was used to investigate the incidence, kernicterus rate and mortality rates of SNJ cohort born between 2000 and 2010.

Results From 2000 to 2010, up to 242 546 patients admitted with neonatal jaundice (NJ) were identified. The incidence of SNJ was 5.9% in 2000 and increased to 13.7% in 2010 (P<0.001). The mortality rate significantly decreased from 0.51% in 2000 to 0.26% in 2010 (P<0.001) and the average incidence of kernicterus was 0.86 per 100 000 live births, indicating dramatically decreased rates compared with earlier rates in Taiwan.

Conclusions In spite of the increased incidence rates, the rates of mortality and kernicterus in patients with NJ significantly declined in Taiwan. The public health prevention programme, clinicians’ awareness and effective management might contribute to the reduction of these acute severe sequelae.

  • neonatal jaundice
  • incidence
  • mortality

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Footnotes

  • Contributors KJH conceptualised and designed the study, reviewed and revised the manuscript, and approved the final manuscript as submitted. PHC conceptualised and designed the study, data collection and analysis, and approved the final manuscript as submitted. PCT carried out the initial analyses, drafted the initial manuscript and approved the final manuscript as submitted. HLY and YCC performed the database operation, data analysis, and approved the final manuscript as submitted. YSS and SHC coordinated, supervised data collection and analysis, and approved the final manuscript as submitted. WJS and MJJ supervised the initial manuscript, and approved the final manuscript as submitted.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Ethics approval This study was approved by the NHRI and the Institutional Review Board of the NHRI (IRB approval number: EC1041107-E).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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