Article Text

PDF
BCG induced lupus vulgaris: an unexpected adverse event
  1. Elaine Pace Spadaro1⇑,
  2. John Xuereb Dingli2,
  3. Rainer Doffinger3,
  4. Kumararatne Dinakantha3,
  5. Alexandra Betts4,
  6. David Pace1
  1. 1Department of Child and Adolescent Health, Mater Dei Hospital, Msida, Malta
  2. 2Gozo General Hospital, Gozo, Malta
  3. 3Department of Clinical Biochemistry and Immunology, Addenbrooke's Hospital, Cambridge, UK
  4. 4Department of Histopathology, Mater Dei Hospital, Msida, Malta
  1. Correspondence to Dr Elaine Pace Spadaro, Department of Child & Adolescent Health, Mater Dei Hospital, Tal-Qroqq, Msida MSD2090, Malta ; elaine.pace-spadaro{at}gov.mt

Statistics from Altmetric.com

A 12-year-old boy presented with a slowly enlarging plaque, at the site of BCG vaccination (Statens Serum Institute, Danish strain 1331), administered 14 months previously (figure 1). Mantoux testing showed a 14 mm induration and his interferon-gamma (IFN-γ) release assay was negative. Skin biopsy revealed non-caseating dermal granulomata composed of epithelioid histiocytes and Langhans-type multinucleated giant cells (figure 2). No acid fast bacilli were seen. PCR for Mycobacterium tuberculosis complex (includes M bovis) was negative. Based on a clinical diagnosis …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.