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Dietary calcium intake influences the relationship between serum 25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH) concentration
  1. Prerna Patel1,
  2. M Zulf Mughal2,
  3. Pinal Patel1,
  4. Bhrugu Yagnik3,
  5. Neha Kajale4,
  6. Rubina Mandlik4,
  7. Vaman Khadilkar4,
  8. Shashi A Chiplonkar4,
  9. Supriya Phanse4,
  10. Vivek Patwardhan4,
  11. Ashish Patel1,
  12. Anuradha Khadilkar4
  1. 1Department of Biotechnology, Hemchandracharya North Gujarat University, Patan, Gujarat, India
  2. 2Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK
  3. 3Department of Biochemistry, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India
  4. 4Hirabai Cowasji Jehangir Medical Research Institute, Jehangir Hospital, Pune, Maharashtra, India
  1. Correspondence to Prerna Patel, Department of Biotechnology, Hemchandracharya North Gujarat University, Patan, Gujarat 384265, India; prernappatel{at}gmail.com

Abstract

Objectives To investigate whether dietary calcium intake will modify the relationship between serum 25-hydroxyvitamin D3 (25OHD) with intact serum parathyroid hormone (PTH) concentrations in apparently healthy Indian adolescents.

Study design Cross-sectional study.

Setting and participants Apparently healthy adolescents aged 10–14 years (n=181), from Gujarat, western India. Study conducted from January 2012 to March 2014.

Methods Serum 25OHD concentrations and intact serum PTH concentrations (both using chemiluminescent microparticle immunoassay) were measured. Diet was recorded through 24 h diet recall and calcium intake was computed (C-diet V.2.1). To assess relationship between 25OHD and PTH, data were dichotomised according to median calcium intakes (520 mg/day) and relationship between serum 25OHD and PTH in the two subgroups was plotted.

Results Subjects with calcium intakes above median (>520 mg/day) had lower intact serum PTH values for given serum 25OHD concentration while those with calcium intakes below median (<520 mg/day) had higher intact serum PTH values for given serum 25OHD concentration. Serum 25OHD concentration was negatively correlated with intact serum PTH concentration at lower as well as higher calcium intakes (r=− 0.606 and −0.483, respectively, p<0.01 for both). Using a regression analysis, predicted values for intact serum PTH concentration for the given serum 25OHD concentrations were plotted. The plot revealed a negative shift with increasing calcium intake.

Conclusions Dietary calcium intake modifies the relationship between serum 25OHD concentrations and intact serum PTH concentrations. Thus, dietary calcium intake should be taken into account when assessing an individual's vitamin D status.

  • Adolescent Health
  • Vitamin D
  • Parathyroid Hormone
  • Calcium

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