Article Text

other Versions

PDF
What a general paediatrician needs to know about early life programming
  1. Thomas C Williams1,
  2. Amanda J Drake2
  1. 1Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK
  2. 2University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, UK
  1. Correspondence to Dr Amanda J Drake, University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen's Medical Research Institute, Edinburgh, EH16 4TJ, UK; mandy.drake{at}ed.ac.uk

Abstract

The process whereby early exposure to an adverse environment has an influence on later life outcomes has been called ‘early life programming’. While epidemiological evidence for this has been available for decades, only in recent years have the mechanisms, in particular epigenetic modifications, for this process begun to be elucidated. We discuss the evidence for early life programming, the possible mechanisms, how effects may be transmitted across generations, and conclude by looking at some examples relevant to general paediatrics.

  • Paediatric Practice
  • Nutrition
  • Obesity
  • Endocrinology
  • Neurodevelopment

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Atoms
    R Mark Beattie