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Successful outcome of renal transplantation in a child with HIV-associated nephropathy
  1. Rukshana C Shroff1,
  2. Mignon McCulloch2,
  3. Vas Novelli3,
  4. Delane Shingadia3,
  5. Suzanne Bradley1,
  6. Margaret Clapson3,
  7. Nizam Mamode4,
  8. Stephen D Marks1
  1. 1Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
  2. 2Department of Paediatric Nephrology, Evelina Children's Hospital, London, UK
  3. 3Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UK
  4. 4Department of Renal Transplantation, Guy's and St Thomas’ NHS Foundation Trust, London, UK
  1. Correspondence to Dr Stephen D Marks, Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK; stephen.marks{at}gosh.nhs.uk

Abstract

Classical HIV-associated nephropathy (HIVAN) was first described before the advent of highly active antiretroviral therapy in late stages of HIV disease with high viral load and low CD4 cell count. Renal transplantation has been successful in a large series of carefully selected HIV-infected adults, with patient and renal allograft survival approaching those of non-HIV-infected patients. We report the successful outcome of living related renal transplantation in a vertically transmitted HIV-infected 8-year-old girl with end-stage kidney disease on haemodialysis due to HIVAN. The pretransplant preparations and post-transplant care, with particular emphasis on immunosuppression and avoidance of opportunistic infections, are discussed.

  • HIV
  • Nephrology
  • HIVAN
  • renal transplantation

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