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Paediatric sepsis-like illness and human parechovirus
  1. Ward Y Vanagt1,
  2. Suzanne PM Lutgens2,3,
  3. Inge HM van Loo2,4,
  4. Petra FG Wolffs2,4,
  5. Gijs ThJ van Well1
  1. 1Department of Paediatrics, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
  2. 2Department of Medical Microbiology, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
  3. 3Laboratory for Medical Microbiology and Immunology, Amphia Hospital Breda, Breda, The Netherlands
  4. 4School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands
  1. Correspondence to Ward Y Vanagt, Department of Paediatrics, MUMC+, PO Box 5800, 6202 AZ Maastricht, The Netherlands; ward.vanagt{at}maastrichtuniversity.nl

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In children with clinical signs of sepsis, inflammatory parameters in blood, bacterial cultures of blood, urine and cerebrospinal fluid (CSF), and viral diagnostics (herpes simplex virus) and enteroviruses (EV) in CSF and EV in faeces) are often examined, mostly followed by hospital admission and empiric antibiotic treatment.

Human parechovirus (HPeV) has been identified and described as cause of sepsis-like illness, meningitis and occasionally encephalitis in children.1 Timely diagnosis of HPeV infection can influence the decision to discontinue antibiotic treatment.

To establish the incidence of HPeV and EV infection, we retrospectively performed PCR analysis on CSF and faecal samples from children (birth to 18 years) with …

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