Aims: To describe the incidence of acute renal insufficiency after dipyrone overdose in children.
Methods: The medical records of all patients up to 18 years of age during a 3-year period presenting at Assaf Harofeh Medical Center due to toxic exposure, were retrospectively reviewed. Patients suffering from dipyrone overdose were compared to all the other patients.
Results: Two hundred and thirty five cases were included in the final analysis. Of these, 26 (11%) patients were exposed to dipyrone (median age 15 years). Three of the 26 patients (12%) had transient nonoliguric renal insufficiency. One other patient who did not receive dipyrone also developed transient renal insufficiency.
Conclusions: Dipyrone overdose is frequent and may cause acute nonoliguric renal insufficiency. Renal function should be monitored in such patients.