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Transient renal insufficiency following dipyrone overdose
  1. Ibrahim Abu-Kishk,
  2. Michael Goldman,
  3. Yair Mordish,
  4. Matitiahu Berkovitch*,
  5. Eran Kozer
  1. 1 Assaf Harofeh Medical Center, Israel
  1. Correspondence to: Matitiahu Berkovitch, Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin, Zerifin, 70300, Israel; fredricag{at}


Aims: To describe the incidence of acute renal insufficiency after dipyrone overdose in children.

Methods: The medical records of all patients up to 18 years of age during a 3-year period presenting at Assaf Harofeh Medical Center due to toxic exposure, were retrospectively reviewed. Patients suffering from dipyrone overdose were compared to all the other patients.

Results: Two hundred and thirty five cases were included in the final analysis. Of these, 26 (11%) patients were exposed to dipyrone (median age 15 years). Three of the 26 patients (12%) had transient nonoliguric renal insufficiency. One other patient who did not receive dipyrone also developed transient renal insufficiency.

Conclusions: Dipyrone overdose is frequent and may cause acute nonoliguric renal insufficiency. Renal function should be monitored in such patients.

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