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Comparison of morphine concentration-time profiles following intravenous and intranasal diamorphine in children.
  1. Susan Kidd1,*,
  2. Thomas Beattie1,
  3. Sarah Brennan1,
  4. Rhona Stephen2,
  5. Robert Minns2
  1. 1 Royal Hospital for Sick Children Edinburgh, United Kingdom;
  2. 2 Department of child Life and Health, University of Edinburgh, United Kingdom
  1. Correspondence to: Susan Louise Kidd, A&E, Royal Hospital for Sick Children Edinburgh, Dept A&E, Royal Hospital for Sick Children Edinburgh, Sceinnes road, Edinburgh, EH9 1LF, United Kingdom; su.kidd{at}dsl.pipex.com

Abstract

Background: Current best practice for treating acute severe pain in children is intravenous (IV) or intranasal (IN) opioid. IN diamorphine offers less traumatic analgesia than the potentially difficult and distressing IV route. However, there has been no direct comparison of IN and IV diamorphine nor are there pharmacokinetic data for IN diamorphine in children.

Objective: To compare plasma morphine concentration-time profiles following IN and IV diamorphine.

Design: Observational.

Setting: City-centre paediatric teaching hospital A&E department.

Patients: Children, aged 3-13 years, with isolated limb fracture.

Interventions: An IV catheter was sited and base-line blood taken. The first 12 children received IV diamorphine (0.1mg/kg), and the subsequent 12, IN diamorphine (0.1mg/kg) in 0.2 ml sterile water drops. Subsequent samples were taken at 2, 5, 10, 20, 30 and 60 minutes.

Measurements: Plasma morphine radioimmunoassay.

Results: Peak plasma morphine concentrations were higher (median 109 vs 36nmol/l), and occurred earlier (median 2 vs 10 minutes), with greater area under the curve (3761 vs 1794nmol/l/h) following IV compared to IN diamorphine (all p<0.0001, Mann-Whitney U test). Higher plasma concentrations at 60 minutes (47 vs 32nmol/l) were also observed following IV diamorphine (p = 0.01, Mann-Whitney U test).

Conclusions: Our evidence supports the wider use of diamorphine by nasal drops in children, showing that adequate plasma levels of morphine are usually achieved. However, we showed significantly attenuated and delayed peak plasma morphine levels with lower levels at one hour compared to IV diamorphine.

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