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High prevalence of Primary Ciliary Dyskinesia in a British Asian population
  1. Chris O'Callaghan (ajb64{at}le.ac.uk)
  1. University of Leicester, UK
    1. Philip Chetcuti (philip.chetcuti{at}leedsth.nhs.uk)
    1. Leeds General Infirmary, United Kingdom
      1. Eduardo Moya (eduardo.moya{at}bradfordhospitals.nhs.uk)
      1. Bradford Royal Infirmary, United Kingdom

        Abstract

        Determining the prevalence of primary ciliary dyskinesia (PCD) in different populations has proved difficult with estimates varying between 1 in 4,000 to 1 in 40,000. The aim of this study was to determine the incidence of PCD in a well defined highly consanguineous Asian population in the UK.

        Over a fifteen year period all patients suspected of PCD in the Asian population of Bradford, UK, were tested by measurement of ciliary beat pattern, frequency and electron microscopy.

        The prevalence of primary ciliary dyskinesia in the population studied was 1 in 2265. 52% of the patient’s parents were first cousins. All patients had a history of chronic cough and nasal symptoms from the first year of life. 73% had a history of neonatal respiratory distress.

        Clinical suspicion of PCD should be high in populations where it is possible that high levels of consanguinity may result in an increase in those with PCD. In these communities the combination of chronic cough and nasal symptoms should prompt early diagnostic testing.

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