Article Text

other Versions

PDF
A protective effect of breastfeeding on progression of nonalcoholic fatty liver disease.
  1. Valerio Nobili (nobili66{at}yahoo.it)
  1. Liver Unit, “Bambino Gesù” Children’s Hospital and Research Institute, Rome, Italy
    1. Giorgio Bedogni
    1. Liver Research Center, Basovizza, and Department. of Life Sciences, University of Trieste, Italy
      1. Anna Alisi
      1. Liver Unit, “Bambino Gesù” Children’s Hospital and Research Institute, Rome, Italy
        1. Andrea Pietrobattista
        1. Liver Unit, “Bambino Gesù” Children’s Hospital and Research Institute, Rome, Italy
          1. Arianna Alterio
          1. Liver Unit, “Bambino Gesù” Children’s Hospital and Research Institute, Rome, Italy
            1. Claudio Tiribelli
            1. Liver Research Center, Basovizza, and Department. of Life Sciences, University of Trieste, Italy
              1. Carlo Agostoni
              1. Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy

                Abstract

                Objective: Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver disease characterized by accumulation of large-droplet fat in hepatocytes with possible progression to inflammation and fibrosis. Breastfeeding has benefits on child health, both during infancy and later in life, reducing the risk of manifestations of the metabolic syndrome. Here we investigated the association between early type of feeding (breast- vs. formula-fed and duration of breastfeeding) and later NAFLD development.

                Study design: We investigated 191 young Caucasian children (3-18 years) with NAFLD consecutively enrolled between January 2003 and September 2007 in our Centre. Forty eight percent of them (n = 91) had been breastfed for a median (interquartile range) time of 8 (7) months.

                Results: After correction for age, waist circumference, gestational age and neonatal weight, the odds of NASH (OR = 0.04, 95%CI 0.01 to 0.10) and fibrosis (OR = 0.32, 95%CI 0.16 to 0.65) were lower in breastfed vs. not breastfed infants. Moreover, the odds of NASH (OR = 0.70, exact 95%CI 0.001 to 0.87) and fibrosis (OR = 0.86, exact 95%CI 0.75 to 0.98) decreased for every month of breastfeeding.

                Conclusions: This observational study suggests that earlier feeding habits might affect the clinical expression of NASH from 3 to 18 years later, with an apparent drug-like preventive effect of breastfeeding.

                Statistics from Altmetric.com

                Request permissions

                If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.