Article Text

other Versions

PDF
With new prenatal testing, will babies with Down syndrome slowly disappear?
  1. Brian G Skotko (brian.skotko{at}childrens.harvard.edu)
  1. Children's Hospital Boston & Boston Medical Center, United States

    Abstract

    An expansive menu of prenatal tests for Down syndrome (DS) is already available to pregnant women around the globe, but new tests are likely to become the most popular entrées. Presently, pregnant women can choose among the many prenatal screening tests—triple screen, quadruple screen, first-trimester combined screen, stepwise sequential screens, and fully integrative screens—to receive statistical chances that their fetuses have DS, to varying degrees of detection (Table 1).1 For a definitive prenatal diagnosis of DS, however, women currently have just two options, both of which are invasive: chorionic villus sampling (CVS), generally performed between 9 and 12 weeks of gestation, and amniocentesis, traditionally offered between 15 and 20 weeks of gestation. By nature of being invasive, both of these diagnostic tests carry small, albeit real, risks of spontaneous abortions.2-7

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.