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Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention
  1. Thomas Reinehr (t.reinehr{at}kinderklinik-datteln.de)
  1. Vestische children's Hospital, Germany
    1. Anke Hinney
    1. Department of Child and Adolescent Psychiatry, Germany
      1. Andre Michael Toschke
      1. King’s College London, Division of Health and Social Care Research, United Kingdom
        1. Johannes Hebebrand
        1. Department of Child and Adolescent Psychiatry, Germany

          Abstract

          Objective: Obesity is considered as a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNPs) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce.

          Methods: We analyzed the effect of two different SNPs (INSIG2:rs7566605, FTO:rs9939609) on the change of weight status in a one-year lifestyle intervention among 280 overweight children (mean age 10.8years, mean BMI 28.1kg/m²).

          Results: The children reduced their mean SDS-BMI by -0.28 (95%CI -0.32 to -0.23). Modeling the impact of different genotypes and their statistical interactions on SDS-BMI change adjusting for age, gender and baseline BMI or SDS-BMI, respectively, revealed that the combination of CC-genotype in INSIG2 and AA-genotype in FTO was significantly associated with the lowest degree of overweight reduction, but even with increase in overweight (SDS-BMI change +0.51 (95%CI 0.22 to 0.79).

          Conclusions: These findings provide some evidence that effects of different genotypes aggravate each other concerning weight change.

          Results: The children reduced their mean SDS-BMI by 0.28±0.02. The frequencies were 7% CC-genotype for INSIG2 and 26% AA-genotype for FTO. Modeling the impact of different genotypes and their statistical interactions on SDS-BMI change adjusting for age, gender and baseline SDS-BMI revealed that the combination of CC-genotype in INSIG2 and AA-genotype in FTO was significantly associated with the lowest degree of overweight reduction (SDS-BMI +0.60±0.18; p=0.001; BMI +3.24±1.26/m²; p=0.011).

          Conclusions: These findings provide some evidence that effects of different genotypes aggravate each other concerning weight change.

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