Objectives: To determine tolerance rates to cow¡¯s milk and soy and to suggest guidelines for follow up-oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).
Methods: The authors analyzed the data of 23 infantile FPIES patients who underwent two or more FU-OFCs and were followed up until over 2 years of age. First FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow¡¯s milk (n = 11) and soy (n = 12) challenge starting groups. Second and 3rd FU-OFCs were performed with a 2 month interval in a crossed and switched-over manner.
Results: Tolerance rates to cow¡¯s milk and soy were 27.3% and 75.0% at 6 months of age; 41.7% and 90.9% at 8 months; and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow¡¯s milk and soy intolerance at age 20 and 14 months, respectively.
Conclusions: In infantile FPIES, 1st FU-OFC should be performed with soy at 6-8 months of age and cow¡¯s milk FU-OFC should be conducted at more than 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.