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Prospective follow up-oral food challenge in food protein-induced enterocolitis syndrome
  1. JIn-Bok Hwang (pedgi{at}kmu.ac.kr)
  1. Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Korea, Republic of
    1. Soo Min Sohn
    1. Department of Pediatrics, Dongsan Medical Center, Keimyung University School of Medicine, Korea, Republic of
      1. Ae Suk Kim
      1. Department of Pediatrics, Dongguk University College of Medicine, Gyeongju, Korea, Republic of

        Abstract

        Objectives: To determine tolerance rates to cow¡¯s milk and soy and to suggest guidelines for follow up-oral food challenges (FU-OFCs) in infantile food protein-induced enterocolitis syndrome (FPIES).

        Methods: The authors analyzed the data of 23 infantile FPIES patients who underwent two or more FU-OFCs and were followed up until over 2 years of age. First FU-OFCs were performed at 6 months of age, and patients were randomly allocated to cow¡¯s milk (n = 11) and soy (n = 12) challenge starting groups. Second and 3rd FU-OFCs were performed with a 2 month interval in a crossed and switched-over manner.

        Results: Tolerance rates to cow¡¯s milk and soy were 27.3% and 75.0% at 6 months of age; 41.7% and 90.9% at 8 months; and 63.6% and 91.7% at 10 months, respectively. Patients outgrew cow¡¯s milk and soy intolerance at age 20 and 14 months, respectively.

        Conclusions: In infantile FPIES, 1st FU-OFC should be performed with soy at 6-8 months of age and cow¡¯s milk FU-OFC should be conducted at more than 12 months of age. Infants with FPIES were observed to outgrow food sensitivities during the first 2 years of life.

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